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ProteomicsCavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response
Caveolae-associated protein 3 (cavin3), a putative tumor suppressor protein, is inactivated in most cancers. The molecular basis for its actions remains poorly understood. We characterized the effects on the proteome of cavin3 loss by utilizing genome-edited cells together with label-free quantitati...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD026724 | Pride
Breast cancer Caveolae Cavin proteins Brca1 
ProteomicsMitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which is involved in the early stages of complex IV assembly
Cytochrome c oxidase assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome c oxidase). Although mutations in COA7 have been linked to complex IV assembly defects and neurological conditions such as peripheral neuropathy, ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD031589 | Pride
Cox Heme X-ray crystallography Mitochondria Cytochrome c oxidase Coa7 
ProteomicsSodium carbonate extraction mass spectrometry reveals novel steps in mitochondrial respiratory chain complex III assembly
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or as integral membrane proteins, while others reside...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD028935 | Pride
Proteomic analysis Mitochondria Oxphos (oxidative phosphorylation) Carbonate extraction Respiratory chain assembly Membrane protein 
ProteomicsDissecting the Roles of Mitochondrial Complex I Intermediate Assembly (MCIA) Complex Factors in the Biogenesis of Complex I
Mitochondrial Complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The Mitochondrial Complex I Intermediate Assembly (MCIA) complex, containing assembly factors...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018075 | Pride
Assembly factors Mitochondria Nadh-ubiquinone dehydrogenase Mcia complex Complex i Oxidative phosphorylation 
ProteomicsHIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV
Assembly factors play a critical role in the biogenesis of mitochondrial respiratory chain complexes I-IV where they assist in the membrane insertion of subunits, attachment of co-factors, and stabilization of assembly intermediates. The major fraction of complexes I, III and IV are present together...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD016864 | Pride
Assembly factor Cytochrome c oxidase Hypoxia Respirasome Oxphos 
ProteomicsThe mitochondrial acyl-carrier protein interaction network highlights important roles for LYRM family members in complex I and mitoribosome assembly
NDUFAB1 is the mitochondrial acyl carrier protein (ACP) essential for cell viability. Through its pantetheine-4’-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family. Although many LYRM proteins have been well describe...
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD013706 | Pride
Ap-ms Lyr motif Topographical heatmap Lc-ms Mitochondria Mitoribosome Ndufab1 Respirastory chain 
ProteomicsSplice-Switching Oligonucleotide-mediated Correction of a Deep Intronic Splice-variant in TIMMDC1 in Cells of Patients with Severe Early Onset Neurodegenerative Disorder.
TIMMDC1 encodes the Translocase of Inner Mitochondrial Membrane Domain-Containing protein 1 (TIMMDC1) subunit of complex I of the electron transport chain responsible for ATP production. We studied a consanguineous family with two affected children, now deceased, who presented with failure to thrive...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029707 | Pride
Human Sso Dia Mitochondrial disease Timmdc1 
ProteomicsMitochondrial E3 ubiquitin ligase MARCHF5 controls BAK function independently of BH3-only proteins
Intrinsic apoptosis is principally regulated by the BCL-2 family of proteins, but some non-BCL-2 proteins also serve as important regulators. To identify novel apoptosis regulators, we performed a genome-wide CRISPR-Cas9 library screen, and it identified the mitochondrial E3 ubiquitin ligase MARCHF5...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030246 | Pride
Apoptosis  bak  bcl-2  marchf5/mitol  e3 ubiquitin ligase  mitochondria  bh3 mimetic 
ProteomicsProximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
Membrane contact sites between organelles are critical for transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production. Protein compartmentalization at lipid droplet-mitochondria contact sit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD060912 | Pride
Lipid droplet Fatty acid Lipid metabolism Lipidomics Lipotoxicity Mitochondria Cell metabolism 
ProteomicsComplex II assembly drives metabolic adaptation to OXPHOS dysfunction.
During acute oxidative phosphorylation (OXPHOS) dysfunction, the reverse activity of succinate dehydrogenase (Complex II) maintains the redox state of the Coenzyme Q pool by utilizing either fumarate or oxygen as terminal electron acceptors. The tendency for one over another has been suggested to be...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064675 | Pride
Mitochondria Tca cycle Oxphos Sdh 
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