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ProteomicsProteomic characterization and label-free comparison of outer membrane vesicles from Francisella tularensis subsp. holarctica strain FSC200 isolated from different cultivation conditions
Francisella tularensis is a Gram-negative, facultative intracellular bacterium, causing a severe disease known as tularemia. It is known to secrete unusually shaped nanotubular outer membrane vesicles (OMV) loaded with number of virulence factors and immunoreactive proteins. In this study the nanotu...
ORGANISM(S): Francisella tularensis subsp. holarctica Francisella tularensis subsp. holarctica FSC200 
2019-09-30 | PXD013074 | Pride
Francisella tularensis  fsc200  outer membrane vesicles  stress response 
ProteomicsDeubiquitinating enzymes in human macrophages after Francisella tularensis infection
Ubiquitination/deubiquitination belong to the most important regulatory mechanisms carried out through the attachment/removal of the ubiquitin molecule, respectively. The process is necessary not only to mark molecules for degradation, but also for example to the activation of signaling pathways lea...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043492 | Pride
Human Macrophage Francisella tularensis Lc-ms Host-pathogen 
ProteomicsPleiotropic effect of Francisella ABC transporter gene inactivation on production of glycoconjugates
The present study deals with the cross-talk of polysaccharide biosynthesis pathways of a highly infectious intracellular pathogen Francisella tularensis, the causative agent of tularemia. We have studied the consequences of disrupting the FTS_1402 gene that lies within the putative polysaccharide lo...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2016-02-04 | PXD002123 | Pride
Glycosylation Q-exactive Francisella 
ProteomicsFrancisella tularensis LVS MSMS spectral library for SRM design
This analysis was performed in order to collect a library of MSMS spectra for tryptic peptides derived from Francisella tularensis LVS proteins. Such MSMS library facilities the design and refinement of LC-SRM assays.
ORGANISM(S): Francisella tularensis subsp. holarctica (strain LVS) 
2019-06-04 | PXD001069 | Pride
Francisella tularensis lvs Msms Spectral library 
ProteomicsCross-species proteomic comparison of whole cell lysates, outer membrane vesicles and membrane fractions of Francisella tularensis subsp. tularensis versus subsp. holarctica
Secretion of outer membrane vesicles (OMV) presents an important phenomenon in Gram-negative bacteria and they play multiple roles in their lifestyle including virulence and host-pathogen interaction. Francisella tularensis secretes unusually shaped tubular OMV. We here present a proteomic compariso...
ORGANISM(S): Francisella tularensis Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. holarctica FSC200 
2021-02-08 | PXD022406 | Pride
Q-exactive Schus4 Outer membrane vesicles Fsc200 Cross-species proteomic comparison Francisella tularensis 
ProteomicsThe identification of bacterial protein interaction partners pointed out to new intracellular functions of Francisella tularensis glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phopshate dehydrogenase (GAPDH) is well-known for its involvement in numerous non-metabolic processes inside the mammalian cells. Alternative functions of prokaryotic GAPDH are mainly deduced from its extracellular localization and the ability to bind to selected host proteins. Data...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 Bacteria 
2020-08-31 | PXD019739 | Pride
Interaction partners Francisella tularensis 
ProteomicsFrancisella tularensis DsbA mutant MS/SILAC analysis
Comparison of enriched membrane fractions of Francisella tularensis subsp. holarctica strain FSC200 and its DsbA mutant by SILAC analysis.
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2018-01-15 | PXD007682 | Pride
Q-exactive Silac Francisella tularensis 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis – proteome dataset
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD006759 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD005747 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
ProteomicsHigh-flow LC-MS/MS analyses - Conventional-Flow Liquid Chromatography-Mass Spectrometry for Exploratory Bottom-Up Proteomic Analyses
The major objective of our study was to find out what are the extra costs and what optimization and adjustment steps of a high-flow LC-MS system have to be undertaken to identify a comparable number of proteins as on a nanoLC-MS system.
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD005481 | Pride
Microbore column Hela High-flow Narrow-bore column 
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