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MetabolomicsEcophysiological Study of Paraburkholderia sp. Strain 1N under Soil Solution Conditions: Dynamic Substrate Preferences and Characterization of Carbon Use Efficiency

We used time-resolved metabolic footprinting, an important technical approach used to monitor changes in extracellular compound concentrations during microbial growth, to study the order of substrate utilization (i.e., substrate preferences) and kinetics of a fast-growing soil isolate, Parabu...

2020-09-28 | MTBLS1692 | MetaboLights
MetabolomicsIntegrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Barth syndrome (BTHS) is a rare X-linked recessively inherited disorder caused by variants in the TAFAZZIN gene. The pathogenic variants lead to impaired conversion of monolysocardiolipin (MLCL) into mature phospholipid cardiolipin (CL). The accumulation of MLCL and mature CL deficiency is a diag...

2025-09-08 | MTBLS12953 | MetaboLights
MetabolomicsIsotope tracing-based metabolite identification for mass spectrometry metabolomics

Modern mass spectrometry-based metabolomics is a key technology for biomedicine, enabling discovery and quantification of a wide array of biomolecules critical for human physiology. Yet, only a fraction of human metabolites have been structurally determined, and the majority of features in typica...

2025-08-15 | MTBLS12861 | MetaboLights
MetabolomicsRapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces

BACKGROUND: We describe a new approach to the recovery of information from faecal samples, based on the analysis of the molecular signature generated by rapid evaporative ionisation mass spectrometry (REIMS).

RESULTS: Faecal pellets from five different r...

2022-02-03 | MTBLS1095 | MetaboLights
ProteomicsIdentification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism and has been increasingly involved in non-metabolic processes and diseases. However, AMPK’s direct substrates in non-metabolic contexts are largely unknown. To better understand the AMPK network, we use a chemica...
ORGANISM(S): Homo sapiens (Human) 
2015-10-09 | PXD003019 | Pride
Substrate identification Ampk Phosphorylation Substrate prediction 
GenomicsBR-body enrichment for RNA substrate identification.
BR-body enrichment for RNA substrate identification.
PRJNA551690 | ENA
ProteomicsIdentification of ATG7 as a protein ATG8ylation substrate
Identification of endogenous protein ATG8ylated ATG7 over 100kDa fractions by MS
ORGANISM(S): Homo Sapiens 
PXD065606 |
ProteomicsOptimization of Protein UFMylation Modification Method and Its Application in Substrate Identification in Human Cells
In this study, we generated the UFSP1KO/UFSP2KO HEK293T cell line and validated it as the most suitable cellular model for the screening, identification, and confirmation of UFMylated substrate proteins. Furthermore, exogenous expression of the E3 ligase components UFL1 and DDRGK1 significantly enha...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD070408 | Pride
Ufsp Ufmylation Ufl1 Ddrgk1 Substrate 
ProteomicsIdentification and Characterization of MCM3 as a KEAP1 Substrate
KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified. Because KEAP1 is altered in a number of human ...
ORGANISM(S): Homo sapiens (Human) 
2017-10-12 | PXD003929 | Pride
Hek293t Di-gly Apms Silac Label free quantification 
Proteomicsbroccoli lysate treated with substrate of OMT1
Identification of OMT1 in broccoli through substrate based thermal proteome profiling
ORGANISM(S): Brassica oleracea var. botrytis (Cauliflower) 
2026-04-30 | PXD058938 | Pride
Thermal proteome profiling Omt1 Broccoli Substrate 
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