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ProteomicsAlterations in proteome and proteostasis networks during replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a ce...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD077854 | Pride
Sumo2/3-modified proteome Replicative senescence Imr90 model 
ProteomicsProteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
SUMOylation is a form of post-translational modification involving covalent attachment of SUMO (Small Ubiquitin-like Modifier) polypeptides to specific lysine residues in the target protein. In human cells, there are four SUMO proteins, SUMO1–4, with SUMO2 and SUMO3 forming a closely related subfami...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080699 | MassIVE
UnknownProteomics datasets of developing rat brain: Synaptic proteome and SUMO2/3-ylome.
Not available
S-EPMC9062222 | biostudies-literature
ProteomicsExtensive protein group SUMO modification of repressive chromatin factors distinguishes pluripotent from somatic cells (total proteome)
Post-translational modification by SUMO is a key regulator of cell identity. In mouse embryonic fibroblasts (MEFs), SUMO impedes reprogramming to pluripotency, while in embryonic stem cells (ESCs), it represses the emergence of totipotent-like cells, suggesting that SUMO targets distinct substrates ...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-16 | PXD020287 | Pride
Mef Esc Somatic Total Stem cells Pluripotent Sumo Proteome Chromatin 
UnknownProteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat Brain.
Not available
S-EPMC8650717 | biostudies-literature
ProteomicsProteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
SUMOylation is a form of post-translational modification involving covalent attachment of SUMO (Small Ubiquitin-like Modifier) polypeptides to specific lysine residues in the target protein. In human cells, there are four SUMO proteins, SUMO1–4, with SUMO2 and SUMO3 forming a closely related subfami...
ORGANISM(S): Homo sapiens (Human) 
2014-12-09 | PXD000716 | Pride
Proteomics Sumo2 Replication stress 
ProteomicsProteomic identification of an endogenous synaptic SUMOylome in the developing rat brain
Synapses are highly specialized structures that interconnect neurons to form functional networks dedicated to neuronal communication. During brain development, synapses undergo activity-dependent rearrangements leading to both structural and functional changes. Many molecular processes are involved ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-25 | PXD028804 | Pride
Post-translational modification Developping rat brain Synapse Sumo 
ProteomicsIP of endogenous SUMO2/3 in HEK293 cells
Aim of the experiments was to identify endogenously SUMO2/3 modified proteins in HEK293 cells. Cells were treated with dexamethasone (dex) or vehicle (etoh) and with heatshock (+43C, HS) or normal growth temperature (+37C, non-HS). Cells were induced with tetracycline to express BirA*-GR (glucocorti...
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD017714 | Pride
Sumo2/3 Heatshock Immunoprecipitation Hek293 
ProteomicsChanges to SUMO-modified proteome and total cellular proteome during EBV ractivation in AGS gastric carcinoma cells
To monitor changes to cellular and viral SUMO-modified proteins during EBV reactivation. SUMO1 and SUMO2 conjugates were studied using KGG mutant forms of SUMO and GG-K specific antibody enrichment of SUMO modified peptides. Time-points of 12h and 24h post-reactivation were monitored. Total cellular...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD034631 | Pride
Sumo epstein-barr virus ebvhuman herpes virus 4 hhv4 
ProteomicsCharacterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...
ORGANISM(S): Homo sapiens (Human) 
2017-09-07 | PXD007629 | Pride
Human embryonic kidney (hek) suspension cells Sumo2 
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