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ProteomicsMechanism of recovery following human stem cell-derived extracellular vesicle treatment to cerebral ischemia
Characterization of hMSC cell and EV revealed that hypoxia preconditioning upregulated 41 expression of metabolic proteins related to HIF signaling, neurogenesis and EV biogenesis.
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD041677 | Pride
Human mesenchymal stem cells  extracellular vesicles  hypoxia  ischemia 
ProteomicsEngineering Extracellular Vesicles by Three-dimensional Dynamic Culture of Human Mesenchymal Stem Cells
Extracellular vesicles (EVs) contain proteins, enzymes and metabolites that contribute to the therapeutic potential of human mesenchymal stem cells (hMSCs). However, scale-up production of hMSC EVs has become a major challenge. In current study, hMSCs were grown as 3D aggregates under wave motion to...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD028975 | Pride
Biogenesis Human mesenchymal stem cells Extracellular vesicles Immunomodulation 3d aggregates Rejuvenation 
GenomicsType I Interferon induces binding of STAT1 to Bcl6: Divergent Roles of STAT-family transcription factors in the T follicular helper cell genetic program
CD4+ T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although seve...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-51531 | biostudies-arrayexpress
ProteomicsEBV Latent membrane protein1 modifies EV content
Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of...
ORGANISM(S): Homo sapiens (Human) 
2020-11-03 | PXD021914 | Pride
Exosomes Hk1 Lmp1 Extracellular vesicles Ebv Evs 
UnknownH2A.B is a cancer/testis factor involved in activation of ribosome biogenesis in Hodgkin Lymphoma
Not available
S-SCDT-EMBOR-2021-52462V1 | biostudies-other
TranscriptomicsImmune cells direct epithelial maturation during early human lung development
The adult human lung harbours a significant proportion of immune cells, which are known to play a crucial role in both normal lung homeostasis and pathogenesis. In this work, we collected CD45-enriched human lung cells from 6 to 22 week post conception (pcw) and built a single-cell transcriptome and...
ORGANISM(S): Homo sapiens 
2022-12-09 | E-MTAB-11528 | biostudies-arrayexpress
UnknownRe-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction
Not available
S-SCDT-EMBOJ-2019-103420P | biostudies-other
ProteomicsPeli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis
The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis since the knock-out induced less activated microglia and less inflammation in the CNS of experimental autoimmune encephalomyelitis in mice. In the present study the brain proteomes of Peli1...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003710 | Pride
Tmt Label-free Eae Cns Peli1 Multiple sclerosis Quantitative proteomics 
ModelsDvarak2020 - PXR targeting using microbial metabolite mimicry
this is a model in the PDB format.
2020-04-03 | MODEL2002050001 | BioModels
ProteomicsProteogenomic analysis of chemo-refractory high grade serous ovarian cancer
To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...
ORGANISM(S): Homo Sapiens 
2023-09-18 | PXD040742 | panorama
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