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ProteomicsTargeted mass spectrum on activation-state-dependent Integrin alpha 5
Integrin alpha 5 is a key transmembrane protein that mediates cell-ECM adhesion and ECM assembly. Its activation and signaling involve both cytoplasmic and extracellular proteins. Using zebrafish somitogenesis as the physiological setting, we sought to identify activation-state-dependent Integrin al...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-10-13 | PXD058550 | Pride
Integrin activation Zebrafish somite Integrin alpha 5 Actin adaptor Integrin actin linker Integrin 
ProteomicsProteomics of zebrafish early somites
The segmented pattern of the vertebral column and musculature in vertebrate embryos is established during somitogenesis. Here, using the model animal zebrafish, we employed Data-Independent Acquisition (DIA) to capture the proteomics change at the early stages of somite development.
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-10-13 | PXD058516 | Pride
Somites Zebrafish 
ProteomicsTargeted mass spectrum on activation-state-dependent Integrin alpha 5
Integrin alpha 5 is a key transmembrane protein that mediates cell-ECM adhesion and ECM assembly. Its activation and signaling involve both cytoplasmic and extracellular proteins. Using zebrafish somitogenesis as the physiological setting, we sought to identify activation-state-dependent Integrin al...
ORGANISM(S): Danio Rerio 
2025-11-10 | PXD058747 | panorama
MetabolomicsPhotosystem - driven resilience of green microalga Tetraselmis chuii toward acute nonylphenol stress

Anthropogenic chemicals pose a threat to aquatic ecosystems by targeting the microalgal photosynthetic engines that drive primary production. Although the toxic effects of pollutants such as nonylphenol (NP) are well-acknowledged, the molecular mechanisms enabling microalgal resilience remain lar...

2026-01-29 | MTBLS13769 | MetaboLights
MetabolomicsStudy on the Hepatoprotection of Schisandra chinensis Caulis Ploysaccharides in nonalcoholic fatty liver disease in rats based on metabolomics

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
ProteomicsProteomic Analysis of Integrin a5 Associated Complexes Dependent upon Integrin Activation State in Zebrafish
Integrins are a major class of heterodimeric adhesion receptors composed of an a and b subunit that link the extracellular matrix (ECM) and the cytoskeleton across the cell membrane. When activated by either the intracellular (inside-out signaling) or extracellular (outside-in signaling) environment...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-10-13 | PXD065495 | Pride
Integrin activation Lc-msms 12 somite stage Integrin a5 Zebrafish Cell adhesion Extracellular matrix 
ProteomicsThe key clock component ZEITLUPE negatively regulates ABA signalling by degradation of the chloroplast outer membrane-localized CHLH/ABAR in Arabidopsis
Firstly, we immunoprecipitated the ZTL protein in ZTL-overexpressing plants (with a YFP tag at the C-terminus of ZTL). Then, the total proteins were identified by MS.
ORGANISM(S): Arabidopsis Thaliana 
PXD029110 |
ProteomicsTFAM-Associated Mitochondrial Dynamics and Metabolic Reprogramming Regulate Microglial Polarization: Temporal and Causal Perspectives
The polarization state of microglia exerts an influence on neuroinflammation and neural tissue repair after injury. Modulating microglial polarization is emerging as a potential therapeutic strategy for various types of neural injuries and neurodegenerative diseases. However, the causal relationship...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072378 |
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