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ProteomicsIdentification of PAC1 interactome in activated T cells
To examine the molecular mechanisms by which PAC1 suppresses T cell response to antigen, we conducted immunoprecipitation followed by mass spectrometry to characterize PAC1-associated proteins in activated T cells
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD012201 | Pride
Pac1 T cells Interactome 
ProteomicsDeep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Mus musculus (Mouse) 
2020-04-16 | PXD018590 | Pride
Tmt-lc/lc-ms/ms Brain Ad mouse model 
ProteomicsIdentification of proteins affected by PTENα under stress conditions by mass spectrometry
Stress granules are known to be related with selective translation. To determine which proteins are regulated by stress granules assembly in Ptenα─/─ MEFs, we performed a mass spectrometry analysis of Ptenα+/+ and Ptenα─/─ MEFs under oxidative stress.
ORGANISM(S): Mus Musculus 
2020-10-03 | PXD021840 |
ProteomicsIdentification of PTENα associated proteins under stress condictions in B16 cells by mass spectrometry
PTENα is the first isoform of tumor suppressor PTEN. To investigate the molecular mechanism by which PTENα modulates cell response to inflammation, we performed pull-down assays with FLAG-tagged proteins coupled with mass spectrometry under condition of H2O2 treatment in B16 cells.
ORGANISM(S): Mus Musculus 
2021-07-13 | PXD040709 |
ProteomicsOverexpress S-protein tagged mouse TBK1 protein and identify the TBK1-interacting proteins by mass spectrometry
HEK293T cells were transfected with SFB-tagged mTBK1 or an empty vector for 24 h, the cells were lysed with lysis buffer (20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5% Triton X-100, 10% glycerol, 1 mM ethylenediaminetetraacetic acid) containing a complete protease inhibitor cocktail, followed by centrif...
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-10-27 | PXD045961 |
ProteomicsQuantitative proteomic analysis reveals the inflammatory regulation and immune activation of mild magnetic hyperthermia in bladder cancer
Inflammatory responses and immune regulation in bladder cancer treatment are critical to therapeutic efficacy, yet their specific mechanisms and protein-level changes remain unclear. Previous studies have shown that an immunosuppressive tumor microenvironment and excessive neutrophil infiltration le...
ORGANISM(S): Mus Musculus 
2025-11-05 | PXD070387 |
ProteomicsLong-term exposure to biodegradable polylactic acid microplastics promotes Microcystis aeruginosa proliferation
Biodegradable plastics, such as polylactic acid (PLA), are widely considered as sustainable alternatives to fossil fuel-derived polymers; however, their degradation generates polylactic acid microplastics (PLA-MPs), which raises ecological concerns in freshwater ecosystems. In this study, we investi...
ORGANISM(S): Microcystis Aeruginosa 
2025-10-15 | PXD069473 |
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
ProteomicsHs_U1snRNP_AD
U1 Small Nuclear Ribonucleoprotein Complex and RNA Splicing Alterations in Alzheimer Disease
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005157 | PeptideAtlas
ProteomicsMethylcobalamin protects against liver failure via engaging gasdermin E
To probe the binding sites of MeCbl on GSDME, 0.4 μM recombinant human GSDME (CSB-EP006766HU) purchased from CUSABIO (Wuhan, China) was incubated with 10 μM MeCbl in 100 μL buffer (20 mM HEPES, 150 mM NaCl and 50 μM DPA) at room temperature for 2 h and protected from light. 0.4 μM recombinant human ...
ORGANISM(S): Homo Sapiens 
2024-11-11 | PXD057768 |
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