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UnknownSurA is a cryptically grooved chaperone that expands unfolded outer membrane proteins.
Not available
S-EPMC7668074 | biostudies-literature
ProteomicsStreptococcus pneumoniae and IAV co infection induces altered polyubiquitination in A549 cells
Epithelial cells are the first line of defense within the lung. Disruption of the epithelial barrier by pathogens enables the systematic dissemination of bacteria or viruses within the host, leading to severe diseases with fatal outcomes. Thus, the lung epithelium can be damaged by seasonal and pand...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD028465 | Pride
Co infection A549 Ubiquitin Influenza a virus Streptococcus pneumoniae d39 
ProteomicsTic20-like proteins mediate organelle assembly in Alphaproteobacteria
Organelle-specific protein translocation systems are essential for the biogenesis of many organelles in eukaryotes but thought to be absent from prokaryotic organelles like magnetosomes. Here, using evolutionary analyses, we show that magnetosomal MamF-like proteins represent members of the widespre...
ORGANISM(S): Magnetospirillum gryphiswaldense 
2024-11-19 | PXD032959 | Pride
Mart Magnetosomes Organelles Protein translocation Mamj Tic20 Duf4870 Magnetokeleton 
ProteomicsNeutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/or phenotype to the surrounding environment. Hyper-virulent streptococcal pyrogenic exoto...
ORGANISM(S): Streptococcus pyogenes M1 GAS Homo sapiens (Human) Streptococcus pyogenes MGAS315 
2023-10-24 | PXD040160 | Pride
Speb Necrotizing soft tissue infections Neutrophils Streptococcus pyogenes 
ProteomicsAltered growth and molecular features of Jurkat cells after introduction of the BCR-ABL1 p190 gene fusion
The Philadelphia Chromosome is the result of a balanced reciprocal translocation be-tween the long arms of chromosomes 9 and 22, resulting in the fusion gene BCR-ABL1. Despite its being a hallmark of acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML) and mixed-phenotype acute leukemi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071195 | Pride
Jurkat Bcr-abl1 P190 All 
ProteomicsOral Pathogen ‘Neutralizes’ the Human Innate Immune Defence
Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a v...
ORGANISM(S): Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 
2018-10-15 | PXD009081 | Pride
Peptidylarginine deiminase (ppad) Citrullination Proteome Porphyromonas gingivalis 
ProteomicsOral Pathogen ‘Neutralizes’ the Human Innate Immune Defence
Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a v...
ORGANISM(S): Homo sapiens (Human) 
2018-10-15 | PXD010798 | Pride
Human Neutrophils P. gingivalis Ppad Lc-ms/ms 
ProteomicsThe global Proteome and Ubiquitinome of bacterial and viral co-infected Bronchial Epithelial Cells
Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial viral co infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses. Epithelial cells ...
ORGANISM(S): Homo Sapiens Staphylococcus Aureus Influenza A Virus (a/germany-by/74/2009(h1n1)) Streptococcus Pyogenes 
2022-06-13 | PXD026625 | panorama
TranscriptomicsGene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40512 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40513 | biostudies-arrayexpress
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