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ProteomicsComprehensive proteomics analyses of IL-15 driven activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T cells that protect the gut from pathogens and maintain intestinal homeostasis. The cytokine IL-15 is trans-presented by epithelial cells to IEL in complex with the IL-15 receptor α chain (IL-15Rα) and plays ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-10 | PXD025891 | Pride
Intraepithelial lymphocytes  interleukin-15  quantitative proteomics  coeliac disease  histone ruler  lfq 
ProteomicsBreast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands
Triple negative breast cancer (TNBC) lacks targeted therapy options. TNBC is enriched in breast cancer stem cells (BCSCs), which play a key role in metastasis, chemoresistance, relapse and mortality. γδ T cells hold great potential in immunotherapy against cancer, and might be an alternative to targ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039463 | Pride
Breast cancer stem cells Proteomics Tmt Immune-escape Lc-ms Quantitation Immunotherapy Γδ t cells Phosphoantigens Triple negative breast cancer 
ProteomicsSmall intestinal epithelial cells from C57Bl/6J mice
Total proteome from sorted primary intestinal epithelial cells isolated from the small intestines of 4 C57Bl/6J mice
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD055546 | Pride
Epithelial Mouse Total Small intestine 
ProteomicsRegulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4
Mutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson's Disease (PD) and Crohn's Disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored. Here we developed a flow cytometry-based assay to assess LRRK2 activity in individual cells ...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-04 | PXD056827 | Pride
Inflammation Lrrk2 Il4 
UnknownInflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2
Not available
S-SCDT-10_1038-S44319-025-00473-X | biostudies-other
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