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ProteomicsProteome imbalance of mitochondrial electron transport chain in brown adipocytes leads to metabolic benefits
Adaptive thermogenesis of brown adipose tissue (BAT) is critical for thermoregulation and contributes to total energy expenditure. However, whether BAT has non-thermogenic functions is largely unknown. Here, we describe that mice with a BAT-specific Liver kinase b1 deletion (Lkb1BKO mice) exhibited ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-12 | PXD008599 | Pride
Mouse Mitochondria 
ProteomicsCharacterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly...
ORGANISM(S): Pseudomonas aeruginosa PAO1-VE2 Pseudomonas phage phiKZ 
2024-11-26 | PXD050275 | Pride
Exploris 480 Phage Pseudomonas aeruginosa 
ProteomicsCharacterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly...
ORGANISM(S): Pseudomonas aeruginosa PAO1-VE2 Pseudomonas phage phiKZ 
2024-11-26 | PXD049415 | Pride
Apms Pseudomonas aeruginosa Phage 
ProteomicsCross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila
The intracellular bacterial pathogen Legionella pneumophila (L.p.) manipulates eukaryotic host ubiquitination machinery to form its replicative vacuole. While nearly 10% of L.p.’s ∼330 secreted effector proteins are ubiquitin ligases or deubiquitinases, a comprehensive measure of temporally resolved...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD019217 | Pride
Legionella 
ProteomicsSympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis
Various physiological stimuli, such as cold environment, diet, and hormones, trigger brown adipose tissue (BAT) to produce heat through sympathetic nervous system (SNS)- and -adrenergic receptors (ARs). The AR stimulation increases intracellular cAMP levels through heterotrimeric G proteins and aden...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-12 | PXD009262 | Pride
Mouse Liver Mitochondria Label-free 
ProteomicsLrpprc deficiency in brown adipocytes diminishes cold-induced thermogenesis but improves systemic metabolism
Insufficient mitochondrial quantity in brown adipose tissue (BAT) causes defective thermogenesis and positive energy balance, which is coupled with the development of obesity. Whether disturbance of mitochondrial quality affects BAT function remains unknown. Here, we describe that the brown adipocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-07 | PXD008798 | Pride
Mouse Mitochondria Lcms 
ProteomicsQuantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin regulating protein VASP
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s Disease (AD). While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is sufficient to drive pathology. Currently, the m...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-08 | PXD041205 | Pride
Ubiquitylation Ppis Alzheimer's disease Phosphorylation 
ProteomicsEpigenetic reprogramming shapes the cellular landscape of schwannoma
Cell state evolution underlies tumor development and response to therapy1, but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the peripheral nervous system and are treated with surgery and ionizing radiatio...
ORGANISM(S): Homo sapiens (Human) 
2023-04-18 | PXD014798 | Pride
Human Cancer Lumos Maxquant 
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Ubiquitylation proteomics experiment for HEK293T cells treated with either non-targeting shRNA, or shRNA knockdown of AMBRA1 by two independent shRNA's (shAMBRA1-TRC20, and shAMBRA1-TRC36).
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD022111 | Pride
Orbitrap elite Ubiquitin Human 
ProteomicsKRASG12C inhibition produces a driver-limited state revealing collateral dependencies
Inhibitors targeting KRASG12C are a promising new class of oncogene-specific therapeutics for the treatment of tumors driven by KRASG12C mutations. These molecules react with the mutant cysteine residue by binding covalently to the switch-II pocket present only in the inactive-GDP state of KRASG12C,...
ORGANISM(S): Homo sapiens (Human) 
2020-03-23 | PXD013075 | Pride
Kras Lung cancer Pancreatic cancer 
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