Sort   by:  
 Page size 
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsCoordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the unde...
ORGANISM(S): Mus musculus 
2012-07-12 | E-GEOD-37933 | biostudies-arrayexpress
TranscriptomicsIdentification of in vivo, conserved, TAF15 RNA binding sites and the impact of TAF15 on the neuronal transcriptome
TAF15, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of TAF15 and the assessment of the impact of TAF15 depletion on the neuronal transcriptome. Our ...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43294 | biostudies-arrayexpress
ProteomicsMonosomes actively translate synaptic mRNAs in neuronal processes
In order to deal with their huge volume and complex morphology, neurons localize mRNAs and ribosomes near synapses to produce proteins locally. A relative paucity of polyribosomes (considered the active sites of translation) detected in electron micrographs of neuronal processes (axons and dendrites...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-27 | PXD016552 | Pride
Neuronal processes Monosomes Mrna Protein synthesis 
ProteomicsAltered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation
GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions where it interacts with synaptic proteins/receptors and regulates Ca2+ signaling.
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD042994 | Pride
Membrane contact sites (mcs) Glycosphingolipids (gsls) Proteomics 
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
ProteomicsSurfaceome dynamics and surface trafficking during neuronal development and synaptic plasticity
Surface proteins are of fundamental importance for formation of synaptic connections and activity-dependent plasticity. Here, we used a spatiotemporally resolved cell-surface proteotype analysis to characterize the neuronal surface-exposed proteome, or surfaceome, during neuronal development and syn...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-05 | PXD014790 | Pride
Synapse Surface Neuroproteomics Spatial Surfaceome 
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (miRNA array)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43943 | biostudies-arrayexpress
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (RT-PCR)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43944 | biostudies-arrayexpress
Sort   by:  
 Page size