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ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
ProteomicsPhosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-17 | MSV000085305 | MassIVE
ProteomicsPathogenic human tau in the Line 66 model of frontotemporal dementia
Transgenic human tau in subcellular fractions extracted after electrophoresis of L66 mouse brain extract. For higher sequence coverage trypsin (Tr) and thermolysin (TL) digests were analysed.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-08-13 | MSV000085945 | MassIVE
TranscriptomicsAlzheimer's Disease Dataset
FK506 binding protein 51kDa (FKBP51/FKBP5) is part of a mature heat shock protein 90kDa (Hsp90) chaperone complex that preserves tau. Microarray analysis of human brains reveal that FKBP51 gene expression selectively increased with age and Alzheimer's disease, which correlated with demethylation of ...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress
ProteomicsAnalysis of human tau and age dependent changes in the synaptic and non-synaptic mitochondrial proteomes of the htau model of tauopathy
We investigated the effects of human tau on subcellular populations of the brain mitochondrial proteome in vivo using transgenic htau mice at ages preceding (5 months) and coinciding with (8 months) onset of tauopathy.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD030950 | Pride
Mitochondria Alzheimer's Synaptic Human Tau 
ProteomicsAxonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticity
Tau pathology is a major hallmark of Alzheimer’s disease (AD) and related diseases, called tauopathies. While Tau is normally enriched in axons, somatodendritic missorting of the microtubule-associated protein is a key event in early disease development. Tau missorting promotes synaptic loss and neu...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD053880 | Pride
Proline-rich region 2 Alzheimer’s disease Tau missorting Tau isoforms Synaptic tau Cdc42 Rab11 
Transcriptomicsp53 prevents neurodegeneration by regulating synaptic genes
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective ...
ORGANISM(S): Drosophila melanogaster 
2015-01-06 | E-GEOD-40418 | biostudies-arrayexpress
Proteomics0N4R Tau and 0N4R Tau P301L Neuronal Interactomes
Human non-mutated 0N4R Tau and P301L mutant 0N4R Tau tagged at the N-terminus with eGFP were expressed in mouse (CD1) primary cortical neurons using adeno associated viruses to monitor early changes in the synaptic interactome beforethe onset of neuronal loss. Affinity purification mass spectrometry...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD044959 | Pride
Mouse neurons Human tau Tau Synapse P301l mutation 
ProteomicsIdentification of proteins that interact with extracellularly applied fibrillar Tau assemblies
The microtubule associated protein Tau (MAPT) expressed in neurons is involved in microtubules stabilization, cell morphogenesis and axonal transport. In pathological conditions, Tau assembles into high molecular weight assemblies leading to neuropathological Tau deposits, the hallmark of several n...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-09 | PXD009294 | Pride
Lc-msms Pull-down 1n4r isoform Interacting protein partners Tau fibrils Proteomics 1n3r isoform 
ProteomicsPTMs of Endogenous Tau in Wildtype and hAPP Transgenic Mice
Please Note, if a password is required, please try "a", the generic password for Massive. These data are in support of the manuscript: Post-translational Modifications of Endogenous Tau in Wildtype and Human Amyloid Precursor Protein Transgenic Mice Meaghan Morris*a,b, Giselle M. Knudsen*c, Sumi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2014-07-30 | MSV000078796 | MassIVE
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