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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsTracer-based Metabolomics Technology to Investigate the Role and Mechanism of Fangji Huangqi Tang in Regulating Lipid Metabolism Disorders in MPC-5 Cells
Lipid metabolism disorders play a critical role in the progression of nephrotic syndrome (NS). Although the traditional Chinese medicine formula Fangji Huangqi Tang (FHT) has been shown to restore lipid homeostasis in vivo, its specific molecular targets and effects on dynamic lipid metabolism in po...
2026-09-20 | MTBLS14277 | MetaboLights
ProteomicsIdentification of Ngo-B interacting proteins
Proteins interacting with Nogo-B were identified by CO-IP mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2024-07-29 | PXD046118 | Pride
Nogo-b co-ip ms 
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
ProteomicsIdentification of Siglec-7-ligand candidates on JVM-3 human B cell line by proximity labeling
Siglec-7 is a member of Siglec family of glycan recognition proteins involved in the regulation of natural killer (NK) cell activities. We found Siglec-7 ligand is highly expressed on JVM-3, a B cell chronic lymphocytic leukemia (B-CLL) cell line. In this experiment, we attempted at identifying th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD024690 | Pride
Human Lc-msms Siglec-7 Ligand B cell Sialic acid 
ProteomicsMechanisms research on Huangqin Tang interference with colitis associated colorectal cancer
Although the exact molecular mechanisms of colitis associated col orectal cancer are not fully understood, the chronic inflammation positively correlated with tumorigenesis. The Traditional Chinese Medicine botanical formulation Huangqin Tang has significant anti-inflammatory effects. We investigate...
ORGANISM(S): Mus Musculus 
2022-02-16 | PXD031696 |
GenomicsHigh density copy number analysis and whole exome sequencing of diffuse large B-cell lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) represents the most common form of B-cell non-Hodgkin Lymphoma (B-NHL), accounting for ~30% of the de-novo diagnoses and also arising as a frequent clinical evolution of Follicular Lymphoma (FL). The molecular pathogenesis of DLBCL is associated with multip...

phs000328.v1.p1 | EGA
ModelsTang2019 - Pharmacology modelling of AURKB and ZAK interaction in TNBC
Aurora Kinase B and ZAK interaction model Equivalent of the stochastic model used in "Network pharmacology model predicts combined Aurora B and ZAK inhibition in MDA-MB-231 breast cancer cells" by Tang et. al. 2018. The only difference is cell division and partitioning of the components, which a...
2024-09-02 | BIOMD0000000940 | BioModels
TranscriptomicsGenomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome
Blood genomic profiling has been applied to disorders of the blood and various organ systems including brain to elucidate disease mechanisms and identify surrogate disease markers. Since most studies have not examined specific cell types, we performed a preliminary genomic survey of major blood cell...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-72642 | biostudies-arrayexpress
ProteomicsIdentification of Siglec-E-ligand candidates on BCL-1 mouse B cell line by proximity labeling
Siglec-E is a member of Siglec family of glycan recognition proteins involved in the regulation of myeloid cell activities. Siglec-E preferentially recognizes disialic acid, a glycan epitope consisting of two sialic acids conjugated in alpha2-8 linkage (Zhang JQ et al., Eur J Immunol. 2004, 34:1175...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-25 | PXD013032 | Pride
Lc-msms Siglec-e Mouse Ligand B cell Sialic acid 
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