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Proteomics0N4R Tau and 0N4R Tau P301L Neuronal Interactomes
Human non-mutated 0N4R Tau and P301L mutant 0N4R Tau tagged at the N-terminus with eGFP were expressed in mouse (CD1) primary cortical neurons using adeno associated viruses to monitor early changes in the synaptic interactome beforethe onset of neuronal loss. Affinity purification mass spectrometry...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD044959 | Pride
Mouse neurons Human tau Tau Synapse P301l mutation 
ProteomicsStructure of Tau filaments in Prion protein amyloidoses
In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) and Gerstma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025663 | Pride
Brain Tau Gss Prp-caa Cryo-em Seeding Aprp Neurodegeneration 
GenomicsAPOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
PRJNA1265955 | ENA
ProteomicsProteostasis as a fundamental principle of Tau immunotherapy – study in male mice
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051830 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
ProteomicsAre Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.
It is unclear to what extent Tau molecular pathology in murine models reflect human Tauopathies. Nevertheless, mouse models that overexpress human mutant Tau (P301S and P301L) are widely used in studies of Tauopathies and Alzheimer’s Disease (AD). In this study, we perform an in-depth temporally and...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD033965 | Pride
Are mouse models a surrogate for human disease? a temporal Quantitative and molecular perspective. 
ProteomicsTarget engagement of Tau antibodies induces reversal of proteomic dyshomeostasis in a mouse model of tauopathy
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045799 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
GenomicsAPOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq]
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq]
PRJNA1266081 | ENA
GenomicsThe APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
PRJNA901027 | ENA
TranscriptomicsAPOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid beta pathology in the carrier. However, the specific molecular mechanisms enabling the E3S/S mutatio...
ORGANISM(S): Mus musculus 
2025-06-15 | GSE297721 | GEO
GenomicsAutosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
PRJNA659243 | ENA
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