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GenomicsSomatic Rescue and Cancer Mutations in Telomere Biology Disorders
Somatic Rescue and Cancer Mutations in Telomere Biology Disorders
PRJNA1047678 | ENA
GenomicsTargeted sequencing about core genes involved in telomere biology in colorectal cancer patients
We sequenced the coding exons of core genes involved in telomere maintenance using peripheral blood DNA of 192 CRC patients. The primary sequencing data were generated by using Ion Torrent Personal Genome Machine® (PGM™) platform (Life Technologies, Carlsbad, CA, USA).
EGAS00001002977 | EGA
GenomicsDNA Methylation Variations and Epigenetic Aging in Telomere Biology Disorders
DNA Methylation Variations and Epigenetic Aging in Telomere Biology Disorders
PRJNA932787 | ENA
ProteomicsDrug sensitivity, gene dependency and proteogenomic correlates of the spectrum of telomere maintenance mechanisms in cancer cells
Replicative immortality is a hallmark of cancer, driven by activation of telomere maintenance mechanisms (TMM), that is yet to be therapeutically exploited. To expedite discoveries that will enable development of TMM-targeted therapeutics, we have generated a resource of telomere biology metrics for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD058664 | Pride
Tmm Cancer Proteomics Swath-dia Telomere biology 
GenomicsPUMA-induced apoptosis in telomere biology disorders
PUMA-induced apoptosis in telomere biology disorders
PRJNA1273111 | ENA
GenomicsReduced representation bisulfite sequencing from G0 & G4/G5 CMP
Differential hyper- and hypo-methylation regions in G0 versus G4/G5 CMP The goal of this study is to evaluate changes in CpG methylation profilings of telomere dysfunctional common myeloid progenitor cells (CMP) as compared to their wild type controls Genomic DNA was extracted from sorted CMP popula...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-62392 | biostudies-arrayexpress
ProteomicsWidespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons
Bacteriophage (phage) are viruses that can kill bacteria, but also mediate gene transfer for bacterial evolution. The telomere phages are a curious form using telomere-like structures to replicate their genomes as linear extrachromosomal elements. Here we find that telomere phages are widely distrib...
ORGANISM(S): Klebsiella variicola subsp. variicola 
2025-05-07 | PXD058604 | Pride
Telocin Klebsiella Toxin-antitoxin Bacteriocin Phages Pore-forming Telomere phage 
ProteomicsTEBP-1 and TEBP-2 are double-stranded telomere binders required for fertility
Telomeres are the ends of linear chromosomes and consist of repetitive double- and single-stranded DNA sequences. Telomeres are bound by dedicated protein complexes, such as shelterin in mammals. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with t...
ORGANISM(S): Caenorhabditis elegans 
2021-03-09 | PXD019241 | Pride
Ip-ms  lc-ms/ms 
UnknownA mechanism for telomere-specific telomere length regulation.
Not available
S-EPMC12781880 | biostudies-literature
UnknownATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders.
Not available
S-EPMC11996883 | biostudies-literature
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