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The gene expression of murine splenic myeloid derived suppressor cells treated with Tff2 is characterized. The motivation of the study originates in the fact that Gr1+Cd11b+ myeloid-derived suppressor cells (MDSCs), which resemble immature myeloid cells (IMCs), expand during cancer in response to in...
ORGANISM(S): Mus musculus 
The aim of the study was to investigate whether the trefoil peptide genes, in concerted action with a miRNA regulatory network, were contributing to nutritional maintrenance. Using a Tff2 knock-out mouse model, 48 specific miRNAs were noted to be significantly deregulated when compared to the wild t...
ORGANISM(S): Mus musculus 
NC or A4GNT+THP-1 cells were incubated with TFF2-3xFlag protein overnight at 4℃, then, co-immunoprecipitation with flag beads. Elute fluid was seperated on SDS-PAGE,and Silver Staining were used to screen the differential protein bands , then,the differential protein band was excised and further ide...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD055880 | Pride
Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury
The gene expression of murine splenic myeloid derived suppressor cells treated with Tff2 is characterized. The motivation of the study originates in the fact that Gr1+Cd11b+ myeloid-derived suppressor cells (MDSCs), which resemble immature myeloid cells (IMCs), expand during cancer in response to in...
ORGANISM(S): Mus musculus 
2016-05-30 | GSE47596 | GEO
Pyloric metaplasia, also known as spasmolytic polypeptide-expressing metaplasia (SPEM), arises in the corpus in response to oxyntic atrophy, but its origin and role in gastric cancer remain poorly understood. Using Tff2-CreERT knockin mice, we identified highly proliferative Tff2+ progenitors in the...
ORGANISM(S): Mus musculus 
2026-03-14 | GSE289709 | GEO
Transcriptome expression profile from lungs of mice infected with H7N9 between control and TFF2 treatment groups
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