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ProteomicsMycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and their Microparticles
Tuberculosis (TB) remains a prevalent and lethal infectious disease. The glycobiology associated with Mycobacterium tuberculosis infection of frontline alveolar macrophages is still unresolved. Herein, we investigated the regulation of protein N-glycosylation in human macrophages and their secreted ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD005169 | Pride
Macrophage Proteomics Mycobacterium tuberculosis Tuberculosis Glycoprofiling Microparticle N-glycosylation Exoglycosidase Glycomics Glycoproteome Lc-ms/ms 
ProteomicsGlycoproteomics and proteomics analysis of Colorectal Cancer and adjacent normal FFPE tissues
Non-invasive prognostic markers are needed to improve survival of colorectal cancer (CRC) patients. Towards this goal, we here apply integrative systems glycobiology approaches to tumour tissues and PBMCs from CRC patients and matching controls as well as a CRC patient-derived cell line. The untarge...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059755 | Pride
Colorectal cancer Ffpe Glycoproteomics 
ProteomicsGlycoproteomics and Proteomics analysis of Colorectal Cancer tissues
Non-invasive prognostic markers are needed to improve survival of colorectal cancer (CRC) patients. Towards this goal, we here apply integrative systems glycobiology approaches to tumour tissues and PBMCs from CRC patients and matching controls as well as a CRC patient-derived cell line. The untarge...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051882 | Pride
Proteomics Mass spectrometry Glycoproteomics Colorectal cancer 
ProteomicsGlycoproteomics and proteomics analysis of PBMCs from Colorectal Cancer patients
Non-invasive prognostic markers are needed to improve survival of colorectal cancer (CRC) patients. Towards this goal, we here apply integrative systems glycobiology approaches to tumour tissues and PBMCs from CRC patients and matching controls as well as a CRC patient-derived cell line. The untarge...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051907 | Pride
Proteomics Glycoproteomics Colorectal cancer Pbmcs 
ProteomicsGlycoproteomics and proteomics analysis of LIM2405 Cell Line
Non-invasive prognostic markers are needed to improve survival of colorectal cancer (CRC) patients. Towards this goal, we here apply integrative systems glycobiology approaches to tumour tissues and PBMCs from CRC patients and matching controls as well as a CRC patient-derived cell line. The untarge...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051909 | Pride
Lim2405 Proteomics Glycoproteomics Colorectal cancer 
ProteomicsGlycoproteomics of healthy and Fut8-KO mice platelet lysates
To validate the knockout of FUT8, the core fucosylation enzyme on mice platelets
ORGANISM(S): Mus musculus (Mouse) 
2026-06-04 | PXD064579 | Pride
Glycoproteomics Fut8 Glycopeptide Blood Lysate Core fucosylation Platelet 
ProteomicsSpatiotemporal glycoproteome remodelling in neutrophils
Neutrophils are short-lived yet vital innate immune cells equipped with bioactive glycoproteins packed in cytosolic granules that can readily be mobilised to elicit an effective and timely response against invading pathogens. Since the dynamic glycosylation processes underpinning the dramatic metamo...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD039387 | Pride
Remodelling Neutrophil Glycoproteomics Maturation Granule Glycoproteome 
ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
ProteomicsThe Bimodal Sugar Code of Neutrophil Myeloperoxidase
Myeloperoxidase (MPO), an important diprotomeric glycoprotein in neutrophil-mediated immunity, produces microbicidal hypohalous acids, but the underpinning glycobiology remains elusive. Deep characterisation of neutrophil-derived MPO (nMPO) using advanced mass spectrometry demonstrated that under-pr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-07 | PXD021131 | Pride
Biosynthesis Granulopoiesis Degranulation Neutrophil Activity : myeloperoxidase N-glycosylation N-acetyl-β-d-glucosamine Ceruloplasmin Granule Inhibition 
ProteomicsProtein paucimannosylation is a novel N-glycosylation signature of human cancers
While aberrant protein glycosylation is a recognised characteristic of human cancers, advances in glycoanalytics continue to discover new associations between glycoproteins and tumourigenesis. This glycomics-centric study investigates a possible link between protein paucimannosylation, an under-stud...
ORGANISM(S): Homo sapiens (Human) 
2021-03-07 | PXD014271 | Pride
Cancer / glycomics / glycan / protein paucimannosylation / paucimannosidic glycan 
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