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ProteomicsProteome profiling of RNF213 depleted cells reveals nitric oxide regulator DDAH1 antilisterial activity
RNF213 is a large, poorly characterized interferon-induced protein. Mutations in RNF213 are associated with predisposition for Moyamoya disease (MMD), a rare cerebrovascular disorder. Recently, RNF213 was found to have broad antimicrobial activity in vitro and in vivo, yet the molecular mechanisms b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027130 | Pride
Human Nitric oxide Ddah1 Listeria monocytogenes Listeria Bacteria Rnf213 Infection 
ProteomicsISG15 blocks CoxsackieB virus infection and pathology by metabolic and antiviral reprogramming
ISG15 is a ubiquitin-like modifier strongly upregulated in the type I interferon response. It exerts an antiviral function in the host defense against a wide variety of viruses. Recently, we observed that ISG15 expression restricts coxsackievirusB3 (CV) infection both in vitro and in vivo. ISG15-dep...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2019-12-09 | PXD013259 | Pride
Shotgun proteomics Mouse Coxsackievirus Infection Liver 
ProteomicsA new life-saving role for Glucocorticoid Receptor dimers: repressing STAT1-induced IFN response in the gut
The use of glucocorticoids (GCs), which bind and activate the glucocorticoid receptor (GR), in systemic inflammatory response syndromes (SIRS) is disputed. Mice with a poor transcriptional response of dimer-dependent GR target genes were studied in a model of TNF-induced SIRS. These GR dim/dim mice ...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-01 | PXD008608 | Pride
Isg Inflammatory response Murine ileum Sirs Shotgun proteomics 
ProteomicsExploring omics-identified antigens and mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide for multiple myeloma therapy
Introduction: Natural killer T (NKT) cells and CD8+ T cells are key in the immune response against multiple myeloma (MM), a largely incurable blood cancer. Immunization is a promising strategy to activate these T cell populations. To our knowledge, immunization with mRNA and α-galactosyl ceramide (α...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060156 | Pride
Cancer Myeloma Mouse Immunopeptidomics 
ProteomicsProteomics-based identification of ISG15 modification sites in vivo upon Coxsackie virus infection
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral activity against several clinically relevant viruses. However, its precise mechanism of action during viral infection remains elusive. Upon infection, ISG15 conjugates to protein substrates in covalent manner. We previously f...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2024-05-23 | PXD032078 | Pride
Mouse Virus Isg15 Infection Ubiquitin 
ProteomicsMapping of ISG15 interaction partners by GST pull down coupled to mass spectrometry
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018346 | Pride
Human Isg15 Interactome 
ProteomicsMapping of ISG15 interaction partners by Virotrap coupled to mass spectrometry
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018345 | Pride
Isg15 Virotrap Human Interactome 
ProteomicsNeoantigen targeted dendritic cell vaccine generates durable T cell responses exhibiting the full spectrum of differentiation states in NSCLC patients
Background. Dendritic cell (DC)-based neoantigen vaccination holds potential as a safe and effective adjuvant therapy for patients with early-stage, resectable NSCLC, a tumor type typically characterized by high mutational loads. DCs have the unique ability to elicit robust antitumoral T-cell respon...
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD044799 | Pride
Cancer Lung non-small cell carcinoma Vaccine Neoantigen Human 
ProteomicsNeoantigen targeted dendritic cell vaccine generates durable T cell responses exhibiting the full spectrum of differentiation states in NSCLC patients
Background. Dendritic cell (DC)-based neoantigen vaccination holds potential as a safe and effective adjuvant therapy for patients with early-stage, resectable NSCLC, a tumor type typically characterized by high mutational loads. DCs have the unique ability to elicit robust antitumoral T-cell respon...
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD044794 | Pride
Human Cancer Non-small cell lung cancer Vaccine Neoantigen Dendritic cells 
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