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MetabolomicsChemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species

The central aim in ecometabolomics and chemical ecology is to pinpoint chemical features that explain molecular functioning. The greatest challenge is the identification of compounds due to the lack of constitutive reference spectra, the large number of completely unknown compounds, and bioinform...

2019-12-31 | MTBLS709 | MetaboLights
ProteomicsThe injury environment critically influences the brain-wide input connectome of transplanted neurons
Cell transplantation is a promising approach for reconstruction of neuronal circuits after brain damage. Transplanted neurons integrate with remarkable specificity into circuitries of the mouse cerebral cortex affected by neuronal ablation. However, it remains unclear how neurons perform in a local ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023660 | Pride
Neuronal replacement Circuit mapping Cell therapy Inflammation Transplantation Synaptic yield Injury proteome 
ProteomicsExcessive local host-graft connectivity in aged and amyloid-loaded brain
Transplantation is a clinically relevant approach for brain repair, but much remains to be understood about influences of the disease environment in the host on transplant connectivity. To explore the influence of ageing and amyloid pathology in Alzheimer's disease (AD) we examined graft connectivit...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023407 | Pride
Synaptic connectivity Mouse brain Alzheimer's disease model Aging 
TranscriptomicsTranscription profiling of mouse microglia reveals luteolin has anti-inflammatory and neurotrophic effects on microglia
Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples Experiment Overall Design: RNA from control BV-2 cells, and cells treated for 24h with LPS, Luteolin, or LPS+Lu...
ORGANISM(S): Mus musculus 
2010-01-23 | E-GEOD-18740 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of macrophages derived from WT and Vdr dificient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3 to study molecular mechanisms of macrophage activation
Gene expression profiling of macrophages derived from WT and Vdr deficient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2421 | biostudies-arrayexpress
TranscriptomicsExpression data from stem samples taken from the base and the first internode of Arabidopsis wildtype and wox4-1 plants
Stem samples of wildtype Columbia plants and the wox4-1 mutant (Gabi_462G01) were analyzed in order to draw a connection between general transcriptomic changes during interfascicular formation in the wildtype and WOX4-dependent gene regulation during this process. We used microarrays to identify fac...
ORGANISM(S): Arabidopsis thaliana 
2011-09-29 | E-GEOD-24781 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human endothelial progenitor cells (EPC) vs. human umbilical vein endothelial cells (HUVEC) vs. CD14+ monocytes
Comparison of mRNA expression in human EPC vs. HUVEC vs. human monocytes. Cell-type specific gene expression under basal cell culture conditions (no stimulation). The hybridization was performed with three samples of EPC vs. three samples of HUVEC vs. 3 samples of CD14+ monocytes. â?¢ The origin of ...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-2040 | biostudies-arrayexpress
ProteomicsMulti-center longitudinal quality assessment of MS-based proteomics in plasma and serum
Advancing MS-based proteomics towards clinical applications evolves around developing standardized start-to-finish and fit-for-purpose workflows for clinical specimens. Steps along the method design involve the determination and optimization of several bioanalytical parameters such as selectivity, s...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054073 | Pride
Plasma Serum Round robin study R package mpwr Lc-ms/ms 
ProteomicsGlobal proteomics and SWI/SNF interactomics in Epithelioid Sarcoma (EpS) upon rescue of SMARCB1
DOX-dependently SMARCB1-re-expressing, stable isogenic EpS cell line models were generated and submitted to global proteomic analysis as well as interactome analysis by co-immunoprecipitation of BRG1, one of the SWI/SNF core ATPases after 96h of DOX treatment.
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD053945 | Pride
Swi/snf Smarca4/brg1 Smarcb1 Epithelioid sarcoma 
TranscriptomicsLsd1 coordinates trophoblast development by retaining stem cells in their niche and directing cell fate
Stem cells reside in specific niches providing stemness-maintaining environments. Thus, the regulated migration from these niches is associated with differentiation onset. However, mechanisms retaining stem cells in their niche remain poorly understood. Here, we show that the epigenetic regulator ly...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-38277 | biostudies-arrayexpress
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