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TranscriptomicsT-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy
Background: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development. However, intrinsic molecular and cellular consequences of either TIA1 or...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-43077 | biostudies-arrayexpress
TranscriptomicsTIA proteins drives global and specific translational repression of genes linked to the cell-cycle progression and DNA replication/repair
The reduction of T-cell intracellular antigen (TIA) proteins in transformed cells leads to the acquisition of aberrant cellular phenotypes promoting uncontrolled cell proliferation and tumor growth. Here we show that global and specific translational rates are regulatory gene events that contribute ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-54540 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of TIA-proteins in human HeLa cells
Analysis of gene expression profiles during the course of both TIA-1 and TIAR expression suppression in HeLa cells
ORGANISM(S): Homo sapiens 
2009-02-27 | E-MTAB-93 | biostudies-arrayexpress
TranscriptomicsThe permanent reduction of TIA proteins molds expression transcriptome in HeLa cells
This study provides, for the first time, TIA1 and TIAR linked-transcriptomic analysis by using RNA-Seq next-generation sequencing technology. Illumina RNA-Seq was used to survey transcriptome profiles from permanent TIA1- and TIAR-(shRNA-mediated) deficient HeLa cells. Analysis of the transcriptomes...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-46516 | biostudies-arrayexpress
ProteomicsBlocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA
Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA neurological deficits, wh...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD070754 | Pride
Synapse Tia Microglia Purinergic receptor Atp 
TranscriptomicsCLIP-Seq of human to identify the global RNA binding sites for TIA1 and TIAL1 proteins
Individual nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) and individual nucleotide resolution UV-crosslinking and affinity purification (iCLAP) were used to identify the global RNA binding sites for TIA1 and TIAL1 proteins. HeLa cells were UV crosslinked before lysing and dig...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-MTAB-432 | biostudies-arrayexpress
TranscriptomicsThe permanent reduction of TIA proteins molds expression transcriptome in HeLa cells.
Background: Our recent studies strongly suggest that remodeling in the control of gene expression contributes to the progression of cell phenotypes associated to the transient and permanent knock-down of T-cell intracellular antigen 1(TIA1) and TIA1 related/like (TIAR/TIAL1) proteins. In particular,...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-47664 | biostudies-arrayexpress
GenomicsMicroglia gene-expression after a transient ischemic attack (TIA)
Microglia gene-expression after a transient ischemic attack (TIA)
PRJNA1374083 | ENA
Transcriptomicsmonitoring splicing changes in TIA1/TIAL1 double knockdown vs control HeLa cells
Not available
ORGANISM(S): Homo sapiens 
2010-10-26 | E-MTAB-526 | biostudies-arrayexpress
TranscriptomicsDysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in t...
ORGANISM(S): Mus musculus 
2014-10-06 | E-GEOD-54418 | biostudies-arrayexpress
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