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ProteomicsPAD4 controls tumor immunity via restraining the MHC-II machinery in macrophages
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood if and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we found that peptidylarginine deiminase 4 (PAD4) manifested the highe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD049188 | Pride
T cell Macrophage Pias Checkpoint Mhc Immunotherapy Tumor Pad4 Citrullination Stat1 
ProteomicsQ-TOF/MS detected results of the Lysostaphin and recombinant Lysostaphin-ELP(V)90
This study engineered a recombinant lysostaphin (Lst) variant, Lst-ELP(V)₉₀, as a therapeutic candidate for prosthetic explant biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Compared with the wild-type (WT) lysostaphin, the recombinant construct exhibited markedly i...
ORGANISM(S): Escherichia coli 
2026-08-13 | PXD080789 | Pride
Lysostaphin Elp Mrsa Q/tof/ms Biofilm 
ProteomicsProteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue.
Proteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue from Wilms tumor patients.
ORGANISM(S): Homo Sapiens 
PXD063650 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
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