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TranscriptomicsAn increase in the abundance of Tim23 in Arabidopsis thaliana results in the disruption of complex I and activation of mitochondrial biogenesis.
Analysis of changes in global transcript abundance profiles of 2 week old tim23 OE (overexpressor) and tim23 KO (knock-out) mutant Arabidopsis plants complared to wild-type (Col-0) using Affymetrix GeneChipﾙ Arabidopsis ATH1 Genome Arrays.
ORGANISM(S): Arabidopsis thaliana 
2011-09-01 | E-MEXP-3309 | biostudies-arrayexpress
ProteomicsMapping protein interactions in the active TOM-TIM23 supercomplex
Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported across two membranes. The TOM and TIM23 complexes facilitate the transport of precursor proteins with N-terminal targeting signals into the matrix. During transport, precursors are recognized by the TIM23 complex i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-12-13 | PXD028002 | Pride
Lc-msms Tim Mitochondria Translocation Structural modelling Tom23 Saccharomyces cerevisiae Crosslinking 
ProteomicsAbsolute quantification of peptides from TIM23 or PINK1-3HA using AQUA peptides
To quantify TIM23 and PINK1-3HA in the immunoprecipitates, control or PINK1-3HA expressing HeLa cells were treated with CCCP and subjected to immunoprecipitation with anti-HA antibody bound to magnetic beads. After spiked with 200 fmol stable isotope-labeled AQUA peptides (Cosmo Bio Co Ltd) as stand...
ORGANISM(S): Homo Sapiens (human) 
2023-04-07 | PXD041244 | JPOST Repository
UnknownStructural basis of mitochondrial protein import by the TIM23 complex.
Not available
S-EPMC11495887 | biostudies-literature
UnknownA mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23.
Not available
S-EPMC6375917 | biostudies-literature
UnknownThe Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23.
Not available
S-EPMC2651516 | biostudies-literature
UnknownHotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.
Not available
S-EPMC11675802 | biostudies-literature
UnknownIdentification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria.
Not available
S-EPMC2064306 | biostudies-literature
UnknownActive remodelling of the TIM23 complex during translocation of preproteins into mitochondria.
Not available
S-EPMC2396396 | biostudies-literature
UnknownStructure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism.
Not available
S-EPMC11452300 | biostudies-literature
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