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GenomicsTreponema sp. TIM-1
Treponema sp. TIM-1 Genome sequencing
PRJNA783467 | ENA
TranscriptomicsmicroRNA expression in Tim-3 knockdown RAW264.7 cell
RAW264.7 cell was stably transfected with Tim-3 siRNA(SI) or negative control(NC) and were analyzed for microRNA expression Differerently expressed microRNA in Tim-3 knockdown RAW264.7 cells were summarized and were used for further analysis RAW264.7 cells stably transfected with Tim-3 siRNA(SI) o...
ORGANISM(S): Mus musculus 
2016-01-14 | E-GEOD-76839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila wild type vs TIM-MJD mutants expressing a polyglutamine-expanded neurotoxic protein in the major timeless (tim)-expressing cells after 3 days of training in light-dark (LD) conditions
WT flies or flies of the strain Tim-gal4; UAS-MJD78Q. All samples were collected at ZT16 after 3 days of training in LD conditions.
ORGANISM(S): Drosophila melanogaster 
2008-06-12 | E-GEOD-2422 | biostudies-arrayexpress
TranscriptomicsComparison of Control and Tim-Fbl gene expression profiles
In order to identify genes affected in our model of PANK defficiency we profiled fly heads of female flies control or expressing fumble RNAi by the use of the tim-gal4 driver Female fly heads of the indicated strains were collected at 2 different circadian timepoints, RNA extracted, labeled and hybr...
ORGANISM(S): Drosophila melanogaster 
2015-01-12 | E-GEOD-42037 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Tim-3 knockdown RAW264.7 cell
Investigation of whole genome gene expression level changes in a Tim-3 knockdown RAW264.7 cell, compared to control siRNA transfected RAW264.7 cell. The Tim-3 knockdown of this cell render it hyper-reactive to TLR stimulation. Tim-3 knockdown analyzed in this study are further described in Li Y, Fen...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-42729 | biostudies-arrayexpress
ProteomicsTIM-3 Inhibition Enhances Tumor Progression and Metastasis: A Paradoxical Immune Checkpoint Response
Syngeneic breast tumors were developed by inoculating of 4T1 cells, into the left flank of female Balb/c mice. When tumor volume reached 200-250 mm3, mice were selected randomized way to receive the treatment of anti-TIM-3 monoclonal antibody (mAb) (Clone: RMT3-23, BioXcell, cat. # BE0115, RRID: AB...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD065028 | Pride
Tnbc Brest Lc-ms Mice Tumor Tim-3 
TranscriptomicsExpression data from human lymphoma endothelium and reactive lymph node-derived endothelium
Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mec...
ORGANISM(S): Homo sapiens 
2010-01-14 | E-GEOD-19882 | biostudies-arrayexpress
ProteomicsGlycosite mapping and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. In particular, the T-cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, 3, 4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, their dense...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-27 | PXD039583 | Pride
O-glycoprotein Tim-1 Cancer Mucinase Tim-4 Tim-3 O-glycosylation Immune checkpoint T-cell immunoglobulin and mucin-domain containing Lc-ms/ms Molecular dynamics Mucinome Mucin O-glycoproteomics Mucin domain Checkpoint inhibitor O-glycoprotease 
TranscriptomicsGene expression change induced by TIM-3/galectin-9 interaction in primary AML
Analysis of gene expression change after galectin-9 stimulation in primary CD34+TIM-3+ AML cells Total RNA obtained from purified CD34+TIM-3+ primary AML cells with or without recombinant human galectin-9 stimulation (20hrs) was subjected to transcriptome analysis
ORGANISM(S): Homo sapiens 
2014-10-10 | E-GEOD-62223 | biostudies-arrayexpress
ProteomicsProteome analysis of MT-2-derived extracellular vesicles isolated by Tim-4 affinity purification
Extracellular vesicles were isolated from MT-2 cultured medium by Tim-4 affinity purification. Tim-4 affinity purification fraction (Af-F) and its supernatant fraction (Af-S) were analyzed by proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2024-02-13 | PXD045623 | JPOST Repository
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