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MetabolomicsHigh-confidence untargeted lipidomics of mammalian serum using LC-TIMS-PASEF

This study aimed to establish and validate a robust untargeted lipidomics workflow for the analysis of human serum using reversed-phase liquid chromatography coupled to trapped ion mobility spectrometry time-of-flight mass spectrometry (RP-LC-TIMS-TOF MS). Commercial pooled human serum was used a...

2026-05-26 | MTBLS14002 | MetaboLights
ProteomicsOptimized Time-segment Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry
We introduce a novel approach, termed time-segment acquisition (Seg), to enhance the identification of peptides and proteins in trapped ion mobility spectrometry (TIMS)-Time of flight (TOF) mass spectrometry. Our method exploits the positive correlation between ion mobility values and liquid chromat...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD051790 | Pride
Phosphoproteomics Timstof Ion mobility ms Tims Proteomics 
UnknownOptimized Time-Segmented Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry.
Not available
S-EPMC11811991 | biostudies-literature
UnknownEffective discrimination of gas-phase peptide conformers using TIMS-ECD-ToF MS/MS.
Not available
S-EPMC8596503 | biostudies-literature
ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
ProteomicsOriginal TIMS-TOF pro BSA data sets for MaxLynx, a novel computational proteomics workflow for XL-MS integrated into the MaxQuant environment.
Cross-linking combined with mass spectrometry (XL-MS) provides a wealth of information about the 3D structure of proteins and their interactions. We introduce MaxLynx, a novel computational proteomics workflow for XL-MS integrated into the MaxQuant environment and here we have tested the performance...
ORGANISM(S): Bos taurus (Bovine) 
2022-01-11 | PXD027161 | Pride
Cross-linking 
ProteomicsOnline parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak widths in the range of seconds, while mass spectra are acquired in about 100 microseconds with time-of-fight (TOF) instruments. This allows adding ion mobility as a third dimension of separation. Among several...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-11-06 | PXD010012 | Pride
Tims Pasef Technological 
ProteomicsAlphaTims: Indexing unprocessed trapped ion mobility spectrometry - time of flight data for fast and easy accession and visualization
High resolution mass spectrometry-based proteomics generates large amounts of data, even in the standard liquid chromatography (LC) – tandem mass spectrometry configuration. Adding an ion mobility dimension vastly increases the acquired data volume, challenging both analytical processing pipe...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD027359 | Pride
Software. Time of flight Ion mobility spectrometry Data indexing Mass spectrometry Data visualization 
ProteomicsAn N-acetyltransferase required for N-terminal protein acetylation and virulence in Mycobacterium marinum
Raw and processed data in support of Collars et al., MS-MS/MS files used for manuscript TIMS-TOF Pro acquisition, IAA treated, trypsin digest.
ORGANISM(S): Mycobacterium Marinum (ncbitaxon:1781) 
2023-03-08 | MSV000091442 | MassIVE
ProteomicsExploiting trogocytosis by Immunopeptidomics to profile tumor associated antigens (TAA) actively targeted by tumor specific T cells in leukemia.
We employed PeptiCHIP Immunopeptidomics to profile tumor associated antigens (TAA) actively targeted by tumor specific T cells by exploiting the trogocytosis effect, whereby antigen presenting cells (APCs) nibble portions of the cognate T cell containing the TCR. The antigen presenting cells were th...
ORGANISM(S): Homo sapiens (Human) 
2023-09-07 | PXD035344 | Pride
T cell Leukemia Peptichip Trogocytosis Taa Ligandomics Tcr Hla-i Human Mhc-i Immunopeptidomics 
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