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ProteomicsA Polyamine-mediated Posttranslational Modification Required For Macrophage Tissue Residency – Differential proteome analysis of DHPS deficient macrophages
Tissue resident macrophages (MTRs) regulate tissue repair and homeostasis by clearing cell debris, and are thought to form the first line of defense against pathogens. MTRs form early in life and self-renew locally. However, during tissue damage or disease, bone-marrow derived monocytes enter tissue...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD054670 | Pride
Eif5a Dia Spectronaut Dda spectral library Tissue resident macrophage proteomics Maxquant Label-free quantification Deoxyhypusine synthase (dhps) Hypusine 
ProteomicsBlood-resident macrophages safeguard blood and vessel integrity
Macrophages are essential in immune defence, tissue development, and disease onset and progression. Their function is in part dictated by their microenvironment and origin. Tissue-resident macrophages originate from yolk sac progenitors, persisting in adult organs and tissues mainly through self-ren...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-03-11 | PXD052344 | Pride
Blood-resident macrophages 
ProteomicsA Macrophage-Collagen Fragment Axis Mediates Subcutaneous Adipose Tissue Remodeling
Efficient collagen degradation is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we aimed to further define the mechanism for this collagenolytic process. We show that loss of collagen type-1 (CT1) and incre...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043721 | Pride
Collagen fragments Macrophages Fibrosis Ecm-remodeling Collagen endocytosis Subcutaneous adipose tissue Cd206 
UnknownSingle-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue.
Not available
S-EPMC8350344 | biostudies-literature
ProteomicsA proteomic landscape of macrophage in mouse tissues
Macrophages, locating in essentially all tissues, are critical for innate immune responses and involved in the tissue homeostasis. Distinct macrophages populations in different tissues exhibited diverse gene expressions and biological processes. Previous studies have accessed the molecular signature...
ORGANISM(S): Mus Musculus 
2022-10-28 | PXD021583 |
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_IL102, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210041929 | GPMDB
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_LPS_1, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320019104 | GPMDB
ProteomicsLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
Resident tissue macrophages (RTMs) are organ-specialized phagocytes responsible for the maintenance and protection of residing tissue. It is well established that tissue diversity is reflected by the heterogeneity of RTMs origin and phenotype. However, much less is known about tissue-specific phagoc...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD033010 | Pride
Phagocytosis Proteomics Cathepsins Resident tissue macrophages Phagosome maturation 
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
ProteomicsPhagolysosomal proteomics identifies DHN-melanin-regulated processes in activated macrophage in response to Aspergillus fumigatus conidia
Infection by the human pathogenic fungus Aspergillus fumigatus is initialized by the outgrowth of asexual spores (conidia) into the lung tissue of the immunocompromised host following an inhalation of the airborne conidia. The resident phagocytes, the alveolar macrophages are the first immune cells ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Mus musculus (Mouse) 
2018-03-08 | PXD006134 | Pride
Host-pathogen interactions Aspergillus fumigatus Mycology Lc-ms Phagolysosome Dhn-melanin Macrophage Proteomics 
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