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TranscriptomicsTranscription profiling of human aortic biopsy samples having differing degrees of stiffness
BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-420 | biostudies-arrayexpress
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsmicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD011882 | Pride
Mechanotransduction Mirna Human Homestasis Ago2 Stiffness Huvec 
ProteomicsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Tissue mechanical homeostasis, the concept that cells sense mechanical properties and alter rates of ECM synthesis, assembly and degradation, is of broad interest in biology and medicine, but there is little direct support or insight into mechanisms. Tissue mechanical properties such as elasticity a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD041630 | Pride
Focal adhesions Stiffness-sensing Mechanical homeostasis Extra-cellular matrix Talin 
TranscriptomicsIdentification of candidate genes affecting juvenile wood stiffness in Pinus radiata
Wood stiffness is the most important wood quality trait of forest trees for structural timber production. We investigated genes differentially transcribed in radiate pine trees with distinct wood stiffness using bulked segregant analysis (BSA) and cDNA microarrays. Transcript accumulation in earlywo...
ORGANISM(S): Pinus radiata 
2011-06-01 | E-GEOD-23020 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
ProteomicsSmall extracellular vesicles promote stiffness-mediated metastasis
Tissue stiffness is a critical prognostic factor in breast cancer and is associated with metastatic progression. Here we show an alternative and complementary hypothesis of tumor progression whereby physiological matrix stiffness affects the quantity and protein cargo of small EVs produced by cancer...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD049019 | Pride
Human Breast cancer Extracellular vesicles Tissue stiffness 
ProteomicsRASSF1A controls Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
Lung cancer remains the leading cause of cancer-related death due to poor treatment responses and resistance arising from tumor heterogeneity. Here we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular mat...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012694 | Pride
Cancer stem cells Hippo pathway Extracellular matrix. Stiffness 
TranscriptomicsRNA-seq of human skin fibroblasts from healthy and systemic sclerosis patients with varying matrix stiffness
This study explores how increased matrix stiffness alters fibroblast transcription and its impact on the lineage specification of fibroblast subpopulations in fibrotic skin. Fibroblasts from healthy and systemic sclerosis patients were cultured in a collagen I-based 3D system with varying matrix sti...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14804 | biostudies-arrayexpress
GenomicsFibrin defines tissue stiffness and biomechanical signalling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping
Fibrin defines tissue stiffness and biomechanical signalling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping
PRJNA1265490 | ENA
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