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ProteomicsFast and robust proteome screening platform identifies neutrophil extracellular trap formation in the lung in response to cobalt ferrite nanoparticles
The goal of this study was to investigate the effects of magnetic iron cobalt oxide nanoparticles (cobalt doped Fe3O4 nanoparticles with increasing amounts of cobalt) after pulmonary exposure while in parallel presenting a proteomics platform that is easily transferable to large-scale nanotoxicology...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-26 | PXD016148 | Pride
Tmt Iron cobalt oxide nanoparticles Balf Lung Clinical proteomics Nanoparticles Mouse Murine Label-free Metal oxide nanoparticles Bronchoalveolar lavage fluid 
ProteomicsTMT labeled Comparative Proteomic Analysis Reveals Active Immune Response during Clostridium perfringens type C Infected Piglet Diarrhea
We performed a TMT labeling-based quantitative spleen proteomic analysis of the control group (SC), tolerance group (SR) and susceptible group (SS) to identify the differentially expressed proteins (DEPs), and screened potential molecular markers of piglet spleen tissues in response to C. perfringen...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-05-20 | PXD030745 | Pride
Tmt labeling  proteome  clostridium perfringens type c  piglet diarrhea  immune response  spleen 
ProteomicsScoelicolor A3(2) - Whole organism, normlized TMT (Rioserasetal,molcellproteomics2018)
abundance based on normlized TMT, Interaction consistency score: 8.2, Coverage: 45
ORGANISM(S): 100226 
2018-00-00 | 3141927513 | PAXDB
ProteomicsIdentification of biomarkers of central nervous system damage in mice of benzene poisoning based on TMT proteomics
Benzene is known to be a common toxic industrial chemical, and prolonged benzene exposure may cause nervous system damage. At present, there were few studies on benzene-induced neurological damage. This research aimed to identify protein biomarkers to predict central nervous system damage of benzene...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD046028 | Pride
Benzene poisoning  tmt proteomic  brain  mice 
ProteomicsProteomics profiling based on TMT and PRM reveal crucial biological processes in the leaves of Sophora alopecuroides under salt stress
This project was based on Tandem Mass Tag (TMT) and Parallel Reaction Monitoring (PRM) technologies to study the changes in protein expression of leaves in Sophora alopecuroides under 150 mM NaCl condition treated for 3 days and 7 days. It was worthy of attention that the expression of several trans...
ORGANISM(S): Sophora alopecuroides 
2022-02-14 | PXD027627 | Pride
Tmt Prm Proteomics Sophora alopecuroides Salt stress 
ProteomicsCDKL5 substrates - Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase
Identification of CDKL5 substrates. Immuno-precipitated proteins were TMT labelled and analysed via LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD009327 | Pride
Cdkl5 Tmt Dlg5 map1s Cep131 
ProteomicsAntimycin A-treated vs ETFDH-ko myoblasts TMT
The electron transfer flavoprotein dehydrogenase (ETFDH) is the bottleneck enzyme of fatty acid oxidation (FAO). We performed a TMT 6plex analysis on Antimycin A treated and ETFDH-ko myoblasts (compared to CRL).
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD045588 | Pride
Myoblast Tmt Etfdh Antimycin a 
ProteomicsTMT Screening of Human Samples:SiHa cell
A screen for APOA1 downstream proteins affecting platinum-based chemoresistance using Tandem Mass Tag revealed 64 differentially expressed proteins in SiHa cells, which were subjected to Gene Ontology (annotation, Kyoto Encyclopedia of Genes and Genomes enrichment, subcellular localization, structur...
ORGANISM(S): Cancer 
2022-05-20 | PXD030885 | Pride
Siha cell Tmt screening Human samples 
ProteomicsTMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid inhibition of colorectal cancer
Purpose: Ursolic Acid (UA), a triterpenoid extracted from Hedyotis Diffusa Willd. (HDW), is known for its anti-inflammatory, antioxidant, and antitumor effects. Nevertheless, the mechanisms underlying UA's anti-colorectal cancer (CRC) effects remain insufficiently understood. This study is aim to id...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD063684 | Pride
Colorectal cancer  hedyotis diffusa willd  ursolic acid  rplp1  tandem mass tags 
ProteomicsC2C12 myoblast WT vs ETFDH-ko TMT
ETFDH (electron transfer flavoprotein ubiquinone oxidoreductase) is a 64 kDa protein monomer located in the inner mitochondrial membrane, in charge of transferring the electrons received from the electron transfer flavoprotein ETF to the Coenzyme Q (Q). Pathological mutations in ETFDH lead to Multip...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD041825 | Pride
Mouse Myoblast Tmt Etfdh C2c12 
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