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ProteomicsTAG-TMTpro, a hyperplexing quantitative approach for high-throughput proteomic studies
Isobaric labeling is the most widely used multiplexing quantitative approach in proteomic studies, enabling the comparison of up to 18 samples in a single MS analysis. Expanding the multiplexing capacity is of great necessity for high-throughput proteomic studies. Herein, we establish a novel TAG-TM...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-14 | PXD033711 | Pride
Proteomics Multiplexing quantitative approach Tmtpro labeling 
ProteomicsTMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing
The development of the TMTpro-16plex series expanded the breadth of commercial isobaric tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described 16plex reagents, the proline-based TMTpro molecule can accommodate two additional combinations of heavy carbon and nitrogen iso...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD024275 | Pride
Real-time search Eclipse Byl-719 Pten Kin-193 18plex Tmtpro Mcf10a 
ProteomicsOvercoming the detrimental O-acylation in TMTpro labeling improves the proteome depth and quantification precision.
The advent of TMTpro reagents expands the sample multiplexing capacity and enables quantification of up to 18 samples in a multiplexed manner. Similar to classic TMT reagents, TMTpro reagents contain a tertiary amine group in their mole-cules, which markedly enhances their reactivity toward hydroxyl...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
2023-12-19 | PXD043778 |
UnknownSuper Heavy TMTpro Labeling Reagent: An Alternative and Higher-Charge-State-Amenable Stable-Isotope-Labeled TMTpro Variant.
Not available
S-EPMC8210946 | biostudies-literature
ProteomicsTMTPro Complementary Ion Quantification Increase Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 level
The ability of the TMTPro isobaric labeling reagents to form complementary ions for accurate multiplexed proteomics at the MS2 level was investigated. Human and yeast peptides were labeled in distinct ratios to analyze the effect of interference on the quantification accuracy. A method, TMTProC, was...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-11 | PXD021661 | Pride
Complementary ion quantification Interference-free quantification Multiplexing Tmtpro 
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016940 | Pride
Human Tmtpro Proteomics Sps-ms3 Cell lines 
UnknownTMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing.
Not available
S-EPMC8210943 | biostudies-literature
ProteomicsNHS-Ester Tandem Labeling in One Pot for 48-Plex Proteomics
Stable-isotope labeling strategies are extensively used for multiplex quantitative proteomics. Hybrid isotope labeling strate-gies that combine the use of isotopic mass difference labeling and isobaric tags can greatly increase sample multiplexity. In this work, we present a novel hybrid isotope lab...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024780 | Pride
48-plex proteomics Tmtpro Mtraq 
UnknownTMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.
Not available
S-EPMC7302421 | biostudies-literature
ProteomicsTMTpro16plex Isobaric Labeling Reagents: Attaining New Sample Multiplexing Heights and New Cellular Proteome Depths in Quantitative Proteomics
Isobaric labeling empowers proteome-wide expression measurements simultaneously across multiple samples. Here, an expanded set of 16 isobaric reagents based on a proline backbone (TMTpro) is presented. These reagents have similar characteristics to existing TMT reagents but with increased fragmentat...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016491 | Pride
Tmtpro16 
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