Trans-golgi network

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Research group Proteomics, CEITEC-MU, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic (1)
Stem Cells and Metabolism Research Program and Dept. of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland; (1)
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Seipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights

Label-free proteomics of immuno-purified SYP61-trans-Golgi Network compartment in control condition and upon sphingolipid acyl-chain length reduction by metazachlor.

The trans-Golgi Network (TGN) in plants is a main sorting hub for proteins and lipids. The lipid composition at the TGN is instrumental to the polar sorting of the auxin efflux carrier PIN2 from TGN to the apical membrane. Here, we immuno-purified the full and intact TGN using the TGN-resident synta...

ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress)

2021-12-01 | PXD026252 | Pride

Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated.

Not available

S-EPMC1679680 | biostudies-literature

Priming by IKKβ recruits NLRP3 to the trans-Golgi network to enable NEK7-independent inflammasome activation

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the context of sterile inflammatory conditions. NLRP3 activity is governed by two independent signals: The first signal primes NLRP3, rendering it responsive to the second signal, which then triggers inflammasome form...

ORGANISM(S): Mus musculus (Mouse)

2022-11-17 | PXD035302 | Pride

Human Lc-msms Macrophages Monocytes Innate immunity Nek7 Pattern recognition Inflammasome Nlrp3

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.

Not available

S-EPMC11020649 | biostudies-literature

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network.

Not available

S-EPMC5470045 | biostudies-literature

LDL transcytosis passes through the trans-Golgi network and requires Rab10.

Not available

S-EPMC12510203 | biostudies-literature