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TranscriptomicsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells (Affymetrix)
The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53 network that includes p53 levels, binding, expression and chromatin changes under diverse str...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46493 | biostudies-arrayexpress
ProteomicsA mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
Transcriptional coactivators of YAP/TAZ play key roles in cancers through transcriptional outputs. However, the mechanisms of their transactivation remain unclear, and effective and safe targeting solutions are lacking. Here, we discovered that YAP/ TAZ possess a hydrophobic transactivation domain (...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD060955 | Pride
Cancer therapy Yap/taz Transactivation 
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from embryos with ?CH1 mutation in p300 and/or CBP atreated with hypoxia or dipyridyl (a hypoxia mimetic) and trichostatin A (a histone deacetylase inhibitor) reveals two transactivation mechanisms are responsible for the bulk of HIF-1alpha-responsive gene expression
The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1? and HIF-2? binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive trans...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3318 | biostudies-arrayexpress
TranscriptomicsEnhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
Synthetic transcription factors can be applied to many areas of biotechnology, medicine, and basic research.  Currently, the most common method for engineering synthetic transcription factors has been based on programmable DNA-binding domains of zinc finger proteins, Transcription Activator-Like Ef...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-62448 | biostudies-arrayexpress
ProteomicsIntricate coupling between the transactivation and basic-leucine zipper domains governs the CK2-dependent phosphorylation of ATF4
Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of co-activators and co-repressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these mechanisms, the structural and func...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029704 | Pride
Atf4 Intrinsically disordered domain Phosphorylation Lc-msms 
TranscriptomicsDisrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease
Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification th...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-60691 | biostudies-arrayexpress
GenomicsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46642 | biostudies-arrayexpress
GenomicsRNA variant assessment using transactivation and transdifferentiation
RNA variant assessment using transactivation and transdifferentiation
PRJNA1139201 | ENA
GenomicsImpact of transcriptional mutagenesis on p53 transactivation
Impact of transcriptional mutagenesis on p53 transactivation
PRJNA577617 | ENA
GenomicsThe effect on p53-induced gene transactivation by ARVCF knockdown.
The effect on p53-induced gene transactivation by ARVCF knockdown.
PRJNA524131 | ENA
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