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TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2
HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral b...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4883 | biostudies-arrayexpress
ProteomicsDynamic proximity based interactome of the transcription factor RELA to identify gene-regulatory networks revealed
Using p65-miniTurbo fusion proteins in HeLa cells, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1a-stimulated cells, including many TFs (47 % of all interactors) and > 50 epigenetic regulators belonging to different classes of chromatin remodeling complexes.
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD045888 | Pride
Lc-msms Rela Affinity proteomics Turbo id Genetic networks P65 nf-kb Interactome 
TranscriptomicsTranscription profiling by array of human myometrial cells transfected by NFKB (p65) and CEBP alone and in combination.
Nuclear factor kappa B and C/EBP are two important transcription factors that independently and synergistically regulate different genes. In this experiment the expression of genes will be examined with the overexpression of NFKB (p65) and CEBP alone and in combination.
ORGANISM(S): Homo sapiens 
2010-03-24 | E-MEXP-2160 | biostudies-arrayexpress
TranscriptomicsControlling for gene expression changes in transcription factor protein networks.
The development of affinity purification technologies together with mass spectrometric analyses of the purified protein mixtures (AP-MS) has been used both to identify new protein-protein interactions and to define the subunit composition of protein complexes. Transcription factor protein interactio...
ORGANISM(S): Homo sapiens 
2014-04-24 | E-GEOD-57027 | biostudies-arrayexpress
TranscriptomicsExpression data from WT or p65-/- mouse embryonic fibroblasts (MEFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription, and whether th...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25469 | biostudies-arrayexpress
TranscriptomicsTrap-80-dependence of TNF-alpha-induced genes
In fibroblasts, p65-dependent genes can be sub-divided, depending on whether they are Trap-80-dependent or -independent. To examine the generality of this grouping, we performed a microarray analysis of wild-type and Trap-80 knock-down fibroblasts, before and after stimulation of NF-kappaB activity...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-12697 | biostudies-arrayexpress
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells
This SuperSeries is composed of the following subset Series: GSE35910: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1] GSE35914: Transcription factor Ebf1 regulates differentiation stage-specific signaling, prolifer...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35915 | biostudies-arrayexpress
TranscriptomicsIdentification of LMX1B target genes in a tet-off inducible HeLa cell line and in the mouse kidney
LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies; however, in the absence of in vivo molecular characterization of their regulation, their identity as direct LMX1B targets remains hypothet...
ORGANISM(S): Homo sapiens 
2008-12-03 | E-GEOD-12008 | biostudies-arrayexpress
TranscriptomicsEngineering Material Properties of Transcription Factor Condensates to Control Gene Expression in HEK-293T Cells
Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. We systematically engineered light-inducible transcription factor condensates with different material properties and analyzed their influence on transcription ac...
ORGANISM(S): Homo sapiens 
2024-04-01 | E-MTAB-13905 | biostudies-arrayexpress
UnknownEnhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65.
Not available
S-EPMC9845348 | biostudies-literature
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