Sort   by:  
 Page size 
ProteomicsAdditional precursor purification in isobaric mass tagging experiments by traveling wave ion mobility separation (TWIMS).
We investigated if additional peptide purification by traveling wave ion mobility separation (TWIMS) can reduce precursor contamination using a mixture of S. cerevisiae and HeLa proteomes. In accordance with previous reports on FAIMS-Orbitrap instruments, we find that TWIMS provides a remarkable imp...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2014-06-10 | PXD001047 | Pride
Ims Tmt Ion mobility separation Isobaric mass tag Tandem mass tag Travelling wave ion mobility separation Twims 
UnknownTravelling Wave Ion Mobility-Derived Collision Cross Section for Mycotoxins: Investigating Interlaboratory and Interplatform Reproducibility.
Not available
S-EPMC8154562 | biostudies-literature
UnknownOptimised Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for the Analysis of Proteins/Peptides Directly from Tissue Sections on a Travelling Wave Ion Mobility Q-ToF.
Not available
S-EPMC6276080 | biostudies-literature
ProteomicsExploring Top-Down Mass Spectrometric Approaches To Probe Forest Cobra (Naja melanoleuca) Venom Proteoforms
Three main top-down mass spectrometry methodologies were employed in a proof-of-concept study to characterise selected three finger toxins and phospholipase A2 toxins from the forest cobra (Naja melanoleuca) venom. The novel utility of data-independent acquisition, alternative hybrid ECD-CID fragmen...
ORGANISM(S): Naja melanoleuca 
2024-09-05 | PXD052561 | Pride
Ecd-cid fragmentation Proteoforms Top-down proteomics Cyclic ion mobility Snake venom Data-independent acquisition 
MetabolomicsMetabolomics Characterization of Human Calcific Aortic Valve Stenosis

BACKGROUND: Calcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease in developed countries with significant morbidity and mortality. Given the poor understanding of the pathophysiological processes leading to CAVS, we utilized a joint non-targeted metab...

2020-02-03 | MTBLS1267 | MetaboLights
ProteomicsIn vitro Modelling of Cardiovascular Damage following Hypertensive Disorders of Pregnancy using Cardiac Spheroids and Patient-derived Plasma
Background: Hypertensive disorders of pregnancy (HDP) affect 2-8% of pregnancies and are associated postpartum with ongoing, increased cardiovascular disease (CVD) risk. In this study, we aimed to model HDP-induced CVD and decipher systemic mechanisms, using an advanced 3D in vitro cardiac spheroid ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD051288 | Pride
Proteomics Data independent acquisition Cardivascular disease Spheroids Ion mobility separation 
ProteomicsStructural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable regulated substrate recruitment and subsequent proteasomal degradation. CAND proteins are essential for the efficient and timely exc...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD042178 | Pride
Human Cand1 Cryo-em Hdx-ms 
ProteomicsProteomic analysis of U251 MG glioblastoma cells in the presence and absence of α-fodrin
The cortical cytoskeleton comprises mainly of the spectrin family of proteins. Spectrin and fodrin are members of this family. They support the plasma membrane. Fodrin is expressed in most tissues apart from the erythrocytes. Fodrin has been shown to be important in a wide variety of functions such ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-24 | PXD023457 | Pride
Α-fodrin Lc-ms Shrna U251 mg glioblastoma cells 
ProteomicsFumarate effect on the Escherichia coli proteome at aerobic and anaerobic growth conditions
The changes in protein composition of E. coli were studied in a global proteomic approach for aerobic growth without or with fumarate as carbon source (glycerol + O2, fumarate + O2, respectively) and anaerobic growth without or with fumarate as carbon source (glycerol + DMSO, glycerol + DMSO + fumar...
ORGANISM(S): Escherichia coli 
2019-11-20 | PXD011760 | Pride
Escherichia coli  fumarate metabolism Aerobic/anaerobic growth  c4-dicarboxylates Lc-udmse 
ProteomicsProfiling the proteome of Mycobacterium tuberculosis during dormancy and reactivation
Tuberculosis, caused by Mycobacterium tuberculosis, still remains a major global health problem. The main obstacle in eradicating this disease is the ability of this pathogen to remain dormant in macrophages, and to get reactivated later under immuno-compromised conditions. The physiology of hypoxic...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2015-06-01 | PXD001158 | Pride
Lc-msms Mycobacterium tuberculosis Dormancy Reactivation Quantitative proteomics 
Sort   by:  
 Page size