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MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
ProteomicsTrifunctional lipid derivatives: PEs mi-tochondrial interactome
In this study, we employed chemically synthesized trifunctional lipid probes to identify putative protein partners that interact with lipids in HeLa cells. These probes incorporate three distinct chemical functionalities. First, a coumarin-based “caging” moiety is added to the lipid head group, whic...
ORGANISM(S): Homo sapiens (Human) 
2025-01-21 | PXD059960 | Pride
Phosphatidic-acid Trifunctional lipid Phospholipid Phosphatidylinositol Phosphatidylethanolamine Lipid interactome 
ProteomicsMelatonin targets mitochondrial trifunctional enzyme HADHA to improve lipid metabolism in metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a clinicopathological syndrome characterized by abnormal accumulation of fat within hepatocytes, and there is currently no standardized clinical treatment available. Consequently, there is an urgent need to discover new pharmacologi...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD071550 | Pride
Melatonin Lipid metabolism Non-alcoholic steatotic liver disease 
ProteomicsCharacteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism
Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism
ORGANISM(S): Escherichia coli 
2023-06-29 | PXD038119 | Pride
Ptpa Echa Phosphorylation 
UnknownEngineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA.
Not available
S-EPMC5293562 | biostudies-literature
UnknownSilencing of Mitochondrial Trifunctional Protein A Subunit (HADHA) Increases Lipid Stores, and Reduces Oviposition and Flight Capacity in the Vector Insect Rhodnius prolixus.
Not available
S-EPMC10926480 | biostudies-literature
UnknownTrifunctional lipid probes for comprehensive studies of single lipid species in living cells.
Not available
S-EPMC5320957 | biostudies-literature
UnknownA Trifunctional Linker for Palmitoylation and Peptide and Protein Localization in Biological Membranes.
Not available
S-EPMC7317724 | biostudies-literature
UnknownCharacteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism.
Not available
S-EPMC10325834 | biostudies-literature
UnknownViperin regulates cellular lipid metabolism during human cytomegalovirus infection.
Not available
S-EPMC3731232 | biostudies-literature
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