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ProteomicsExploring the glycosylation state of the Cryptosporidium parvum CpTSP protein family-HILIC glycopeptide enrichment
Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of vaccines to prevent or limit infection remains an important goal for tackling these diarrheal diseases, which are a significant cause of infant morbidity in the developing...
ORGANISM(S): Cryptosporidium parvum Iowa II 
2023-01-12 | PXD023936 | Pride
Cryptosporidium Glycosylation Thrombospondin repeat 
ProteomicsO-Fucosylation of ADAMTSL2 Thrombospondin Type 1 Repeats is Required for Secretion and is Impacted by Geleophysic Dysplasia-Causing Mutations
A disintegrin-like and metalloprotease domain with thrombospondin type 1 repeats-like 2 (ADAMTSL2) is a matricellular protein that interacts with latent TGF-b binding protein 1 and fibrillin-1. ADAMTSL2 mutations cause an autosomal recessive connective tissue disorder named geleophysic dysplasia 1 (...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-01 | PXD018902 | Pride
Geleophysic dysplasia Thrombospondin type 1 repeats Tsr glycosylation Adamtsl2 o-fucosylation 
ProteomicsExploring the glycosylation state of the Cryptosporidium parvum CpTSP protein family-FAIMS proteome
Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of vaccines to prevent or limit infection remains an important goal for tackling these diarrheal diseases, which are a significant cause of infant morbidity in the developing...
ORGANISM(S): Cryptosporidium parvum Iowa II 
2023-01-12 | PXD023935 | Pride
Cryptosporidium Glycosylation Thrombospondin repeat 
ProteomicsExploring the glycosylation state of the Cryptosporidium parvum CpTSP protein family-Cman pulldowns
Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of vaccines to prevent or limit infection remains an important goal for tackling these diarrheal diseases, which are a significant cause of infant morbidity in the developing...
ORGANISM(S): Cryptosporidium parvum Iowa 
2023-01-12 | PXD023934 | Pride
Cryptosporidium Glycosylation Thrombospondin repeat 
ProteomicsTryptophan C-mannosylation is critical for Plasmodium falciparum transmission Dataset1
C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
ORGANISM(S): Plasmodium falciparum 
2022-07-06 | PXD033470 | Pride
Glycosylation Plasmodium falciparum Ookinete Sporozoite Gametocyte Gamete Dpy19 Transmission 
UnknownProtein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.
Not available
S-EPMC6364784 | biostudies-literature
ProteomicsToxoplasma gondii MIC2 TSRs glycosylation
Toxoplasma gondii is an intracellular parasite that causes disseminated infections which can lead to neurological damage in fetuses and immunocompromised individuals. Microneme protein 2 (MIC2), a member of the thrombospondin-related anonymous protein (TRAP) family, is a secreted protein important f...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2018-08-09 | PXD010622 | Pride
O-fucosylation Toxoplasma gondii C-mannosylation 
ProteomicsThrombospondin repeats secreted by C-mannosyltransferase-deficient mammalian cells
C-mannosylation in addition to N- and O-glycosylation is a further but less well studied type of protein glycosylation taking place in the endoplasmic reticulum (ER) characterised by the modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. M...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024192 | Pride
Thbs1 Dpy19l3 Adamts16 C-mannosylation Dpy19l1 Tsr 
UnknownTryptophan C-mannosylation is critical for Plasmodium falciparum transmission.
Not available
S-EPMC9338275 | biostudies-literature
UnknownApicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containing Adhesins of the TRAP Family.
Not available
S-EPMC6018953 | biostudies-literature
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