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MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine
Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and mic...
2026-08-20 | MTBLS10141 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine

Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and ...

2026-08-20 | MTBLS10145 | MetaboLights
MetabolomicsHemocyanin negatively regulates phenoloxidase activation via phenylalanine-tyrosine metabolism to enhance immune defense in AHPND-infected Penaeus vannamei
Hemocyanins function not only as oxygen carriers in the hemolymph of arthropods and molluscs but also as an important multifunctional immune molecule. In this study, we observed a significant increase in hemocyanin expression and a decrease in PO activity in Penaeus vannamei infected with acute hepa...
2026-05-22 | MTBLS14563 | MetaboLights
ProteomicsXL-MS analysis of human tyrosine hydroxylase
Tyrosine hydroxylase (TH) is a highly regulated enzyme that catalyses the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines. Mutations and dysfunction in this enzyme lead to DA deficiency and parkinsonisms of different severity. An understanding of TH deficiency at the...
ORGANISM(S): Homo sapiens (Human) 
2021-12-22 | PXD024519 | Pride
Xl-ms Dopamine Tyrosine hydroxylase Bs3 
ProteomicsStructural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Pathogenic variants of the J-domain protein DNAJC12, a co-chaperone of Hsp70, cause parkinsonism, which seems associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine synthesis. Here, we report the characterization of TH:DNAJC12 complex ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045185 | Pride
Tyrosine hydroxylase Hsp40 Dnajc12 Hsp70 Tyrosine hydroxylase deficiency 
TranscriptomicsAnalysis of mRNA abundance in the wild-type or Phd2 knockout carotid body and adrenal medulla of mice
The mRNA abundance in the wild-type or Phd2 knockout carotid body and adrenal medulla of mice was analysed by RNA-Seq. For this purpose, mice with tyrosine hydroxylase-restricted inactivation of Phd2 were generated. For the preparation of a single RNA-Seq library, RNA from 10 carotid bodies or adren...
ORGANISM(S): Mus musculus 
2023-08-14 | E-MTAB-13163 | biostudies-arrayexpress
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
GenomicsCacopsylla chinensis
UNVERIFIED: Cacopsylla chinensis strain tyrosine hydroxylase gene
PRJNA1290838 | ENA
ProteomicsStructural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Pathogenic variants of the J-domain protein DNAJC12, a co-chaperone of Hsp70, cause parkinsonism, which seems associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine synthesis. Here, we report the characterization of TH:DNAJC12 complex ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD056328 | Pride
Th Dnajc12 
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