Unwinding of dna

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Associate Professor in Chromosome Dynamics and Stability (Genome Damage and Stability) Chromosome Dynamics and Stability Group Genome Damage and Stability Centre University of Sussex Brighton BN1 9RQ (1)
Chromosome Dynamics and Stability Group, Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, United Kingdom (1)
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Department of Molecular Genetics Faculty of Biochemistry Weizmann Institute of Science Rehovot, Israel (1)
Head of the DNA Replication Research Group (1)
Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan. Department of Life Science, National Taiwan University, Taipei, Taiwan. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan (1)
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Stepwise DNA unwinding gates TnpB genome-editing activity

PRJNA1450085 | ENA

Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution

During eukaryotic DNA replication initiation, inactive MCM2-7 double-hexamers assembled at replication origins must be converted into two active CMG helicases, yet how this transition is coupled to origin DNA unwinding in vivo remains unclear. Here, we identify a DNA-bound intermediate with an exten...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2026-06-26 | PXD080178 | Pride

Visualizing helicases unwinding DNA at the single molecule level.

Not available

S-EPMC2910053 | biostudies-literature

SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding.

Not available

S-EPMC9894130 | biostudies-literature

Stepwise DNA unwinding gates TnpB genome-editing activity

TnpB is a compact RNA-guided endonuclease and evolutionary ancestor of CRISPR-Cas12 that offers a promising platform for genome engineering. However, the genome-editing activity of TnpBs remains limited and its underlying determinants are poorly understood. Here, we used biochemical and single-molec...

ORGANISM(S): Escherichia coli

2026-04-17 | GSE327273 | GEO

DNA unwinding mechanism of a eukaryotic replicative CMG helicase.

Not available

S-EPMC7000775 | biostudies-literature

DNA Unwinding Driven by Gold Nanoparticles.

Not available

S-EPMC12735733 | biostudies-literature

The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain.

Not available

S-EPMC3064778 | biostudies-literature

Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive DNA unwinding.

Not available

S-EPMC4687592 | biostudies-literature

Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process.

Not available

S-EPMC10756200 | biostudies-literature

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