Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to explore ChIP-Seq results for H3K27ac in ut7 cell line.
Acute basophilic leukemia is a rare subtype of acute myeloblastic leukemia. We recently described a recurrent t(X;6)(p11;q23) translocation occurring in male infants with acute basophilic leukemia, generating a MYB-GATA1 fusion gene. To better understand the role of MYB-GATA1 in the leukemogenesis o...
Expression data in K562, MV4-11, and UT7-5.3 We used microarrays to investigate the impact of RINF (alias CXXC5) gene silencing on whole gene mRNA expression profile
We construct two stable UT7/Epo-S1 cell lines which could be inducible expressing B19 NS1 and NS1 TAD2 domain mutation proteins. After treated with or without doxycycline induction, we extract the total RNA for RNA-seq analysis.
A significant change in the 5-hmCSeal signal is observed between UT-7 WT cells and cells carrying single or dual phospho-site substitution cells around the BCL11A gene enhancer region.
5q- syndrome is a somatic ribosomopathy linked to the monoallelic deletion of the RPS14 gene and characterized by a proeminent erythroid phenotype. The mechanism of anemia involves an impaired differentiation and increased apoptosis of erythroblasts. We have analyzed total cell extracts from UT7 cel...
