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ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
ProteomicsPhospho-proteome of vascular smooth muscle cells derived from abdominal aortic aneurysm patients
For this experiment, primary smooth muscle cells (SMC) were isolated from abdominal aortic aneurysm (AAA) patients. Control SMC (c-SMC) were isolated from non-dilated human aortas. SMC contraction from AAA-patients and controls was measured. SMC contraction from AAA patients shows a broad range, wit...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD054353 | Pride
Abdominal aortic aneurysm  contractile function  proteomics  vascular biology  vascular smooth muscle cells 
ProteomicsGlobal Phosphoproteomics of BRCA1-deficient mammary tumors in genetic mouse models
The aim of the study is to identify differences in the global phosphoproteome across a BRCA1-deficient mouse mammary tumor panel. We have matched PARPi-naive and PARPi-resistant tumors, in which resistance was induced in vivo (mice bearing tumors were treated with PARPi untill the tumors stopped res...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD032007 | Pride
Brca1 Global phosphoproteomics Rad51 foci Parpi Label-free Dna damage response Gemm 
ProteomicsProteomic profiling of a large cohort of HCM patients: genotype-specific protein changes
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular (LV) hypertrophy and diastolic dysfunction, which leads to LV outflow tract obstruction (LVOTO) in the majority of cases. Mutations in genes encoding sarcomeric proteins cause HCM and are identified in more than half o...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD012467 | Pride
Myectomy Hypertrophic cardiomyopathy Label-free Hcm Spectral counting 
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 4
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. The concentrations of these proteins are combined in the Anti Apoptotic index (AAI). We previously found that th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080266 | MassIVE
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 3
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080268 | MassIVE
TranscriptomicsGene profiling of the early healing rat medial collateral ligament
The objective of the study was to better understand the mechanism behind scar formation by identifying ECM factors and other unique genes differentially expressed during rat ligament healing via microarray. Rat medial collateral ligaments (MCL) were surgically transected or left intact. MCLs were co...
ORGANISM(S): Rattus norvegicus 
2013-06-06 | E-GEOD-47676 | biostudies-arrayexpress
ProteomicsMesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics
Tumor-derived extracellular vesicles (TEVs) play a crucial role in cancer progression, metastasis and therapy resistance but their distinct profiles across different cancer stages and molecular subtypes remain underexplored. This study analyzed TEVs from epithelial (CMS2) and mesenchymal (CMS4) subt...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD057149 | Pride
Tumor-derived extracellular vesicles Proteomic analysis Tspan4 Diagnostic tool Mirna signature Colorectal cancer Consensus molecular subtypes Tspan8 
ProteomicsCharacterization of ESX-1 components EccA1, EspG1 and EspH reveal pivotal role of Esp substrates in the Mycobacterium marinum infection cycle
The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual components and the role of individual substrates is...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2018-08-02 | PXD008905 | Pride
Esx-1 Secretion Label-free quantitation Ecca1  espg1  esph  esxa Mycobactrium marinum 
ProteomicsThe phosphoproteomic landscape of two FLT3+ Acute Myeloid Leukemia (AML) patient samples-LYSATES.
Acute myeloid leukemia (AML) is a clonal hematopoietic malignancy, characterized by expansion of immature leukemic blasts in the bone marrow. In AML, specific tyrosine kinases have been implicated in leukemogenesis, and are associated with poor treatment outcome. However, targeted therapy using kina...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD015662 | Pride
Human Single-shot Tyrosine kinase Flt3 Label-free Phosphoproteomics Acute myeloid leukemia Aml 
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