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TranscriptomicsA single cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs), lining blood vessels, across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomic data from 11 tissues of the model organism Mus musculus. We propose a new classification of EC phenotypes based on transcri...
ORGANISM(S): Mus musculus 
2020-02-13 | E-MTAB-8077 | biostudies-arrayexpress
ProteomicsThe Proteomic Landscape of in vitro Cultured Endothelial Cells across Vascular Beds
Blood vessel endothelial cells (EC) display heterogeneity across vascular beds, which is at the bases of organ specificity and anticipated to drive site-specific vascular pathology. It is assessed in vivo using transcriptomics, and in vitro using functional assays, but how proteomes compare across h...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD045899 | Pride
In vitro Cardiac Brain Aorta Lung Liver Kidney Boec Huvec Endothelial cells 
ProteomicsMolecular profiling of vascular beds in vivo by DISDIVO
We developed a new technique named as Differential Systemic Decellularization in vivo (DISDIVO) for the molecular profiling of vascular beds throughout the body. This method can by applied to murine models. Thus, the data provided here correspond to mice vascular beds obtained in vivo by DISDIVO.
ORGANISM(S): Mus musculus (Mouse) 
2018-12-06 | PXD008794 | Pride
Endothelial dysfunction In vivo Endothelial cells Disdivo Smooth muscle cells Glycocalyx 
TranscriptomicsTrophoblast-Induced Changes in C-X-C Motif Chemokine 10 Expression Contribute to Vascular Smooth Muscle Cell Dedifferentiation During Spiral Artery Remodeling
Endothelial cell and vascular smooth muscle cell were cocultured in hanging droplets to form spheroids representing an inverted vessel lumen. Control or conditioned media from an extravillous trophoblast (EVT) cell line was incubated with vascular spheroids for 24 hours. Spheroid RNA was then analyz...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-MTAB-1462 | biostudies-arrayexpress
ProteomicsCharacterization of proteome dynamics in individual vascular layers at the early stage of acute sepsis
In this study we developed a stable isotope labeled of mammals (SILAM) model coupled to the application of differential systemic decellularization in vivo (DISDIVO) to evaluate the molecular dynamics of whole organism vascular beds at the initial phase of acute sepsis. Three different vascular layer...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-29 | PXD018274 | Pride
Lipopolysaccharide Endothelial dysfunction Disdivo. Endothelial cells Vascular beds 
UnknownStudy protocol for COvid-19 Vascular sERvice (COVER) study: The impact of the COVID-19 pandemic on the provision, practice and outcomes of vascular surgery.
Not available
S-EPMC7773264 | biostudies-literature
TranscriptomicsSlit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle by inducing capillary sprouting and decreasing vascular permeability via reduced eNOS activity
Rationale: Slit2 is a possible modulator of vascular endothelial growth factor (VEGF) - induced angiogenesis, but its effects have not been tested in large animal models. Objective: We studied the effect of Slit2 on therapeutic angiogenesis induced by VEGF receptor 2 (VEGFR2) ligands Vammin and VEGF...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-63283 | biostudies-arrayexpress
UnknownThe in vivo endothelial cell translatome is highly heterogeneous across vascular beds.
Not available
S-EPMC6876253 | biostudies-literature
GenomicsComparative Analysis of In vivo Endothelial Cell Translatomes Across Central Nervous System Vascular Beds (Tie2)
Comparative Analysis of In vivo Endothelial Cell Translatomes Across Central Nervous System Vascular Beds (Tie2)
PRJNA1125400 | ENA
GenomicsComparative Analysis of In vivo Endothelial Cell Translatomes Across Central Nervous System Vascular Beds (Cdh5)
Comparative Analysis of In vivo Endothelial Cell Translatomes Across Central Nervous System Vascular Beds (Cdh5)
PRJNA1125403 | ENA
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