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ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus 
2019-05-01 | PXD010494 | Pride
Ethcd Sars N-linked glycosylation Mers 
ProteomicsHCOV-NL63 spike protein glycopeptides
HCoV-NL63 is a coronavirus that can cause severe lower respiratory tract infections requiring hospitalization. Of great interest is understanding the HCoV-NL63 coronavirus spike glycoprotein trimer, which is the conformational machine responsible for entry into host cells and the sole target of neut...
ORGANISM(S): Human Coronavirus Nl63 (ncbitaxon:277944) 
2020-03-13 | MSV000085098 | MassIVE
ProteomicsHCOV-NL63 spike protein glycopeptides
HCoV-NL63 is a coronavirus that can cause severe lower respiratory tract infections requiring hospitalization. Of great interest is understanding the HCoV-NL63 coronavirus spike glycoprotein trimer, which is the conformational machine responsible for entry into host cells and the sole target of neut...
ORGANISM(S): Human coronavirus NL63 
2016-09-27 | PXD004557 | Pride
Ethcd Glycopeptide Virus 
ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Severe Acute Respiratory Syndrome-related Coronavirus (ncbitaxon:694009) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2020-03-13 | MSV000085097 | MassIVE
ProteomicsGlycopeptides from recombinant EBV gH, gL and gp42 with EThcD
Soluble ectodomains of Epstein Barr Virus glycoproteins gH/gL and gp42 were expressed in HEK293F cells for structural characterization by cryo electron microscopy. The purified material was additionally analyzed by LC-MS/MS after digestion with trypsin or chymotrypsin to identify N-linked glycosylat...
ORGANISM(S): Human herpesvirus 4 
2018-04-10 | PXD006403 | Pride
Glycopeptide  epstein barr virus 
ProteomicsRecombinant HIV-1 426c Env Tryptic Digest Glycan Identifications and Semi-Quantification
VRC01-class broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env) and are of major interest for vaccine design. Unlike mature antibodies, corresponding VRC01-class germline precursors poorly bind to Env d...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2018-11-21 | PXD011494 | Pride
Mannose Immunogen Oligosaccharide Xray crystallography Glycan Vrc01 Hiv-1 Endoh 426c Vaccine Glvrc01 Cryoem Human immunodeficiency virus Hiv Vrc01gl Gp120 
ProteomicsOvercoming steric restrictions of VRC01 HIV-1 neutralizing antibodies through immunization
Broadly HIV-1 neutralizing VRC01-class antibodies target the CD4-binding site of Env. They are derived from VH1-2*02 antibody heavy chains paired with rare light chains expressing five amino acid long CDRL3s. They have been isolated from infected subjects but have not yet been elicited by immunizati...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2020-05-26 | PXD015168 | Pride
Immunization Hiv N276 Glycan Vrc01 426c core Mice Antibody Bnab 
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