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UnknownNew Red-Emitting Chloride-Sensitive Fluorescent Protein with Biological Uses.
Not available
S-EPMC8478333 | biostudies-literature
ProteomicsA post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play central roles in RNA regulation, including translation and turnover. Here we ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD007270 | Pride
Shrna Lc-ms Hescs 
UnknownCombined Use of a Bacterial Consortium and Early-Colonizing Plants as a Treatment for Soil Recovery after Fire: A Model Based on Los Guajares (Granada, Spain) Wildfire.
Not available
S-EPMC10452388 | biostudies-literature
ProteomicsIdentification of ubiquitination sites of purified histone H3
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018621 | Pride
Epigenetics Ubiquitination Histone h3 
ProteomicsThe ubiquitin ligase UBR5 suppresses proteostasis collapse in immortal pluripotent stem cells and Huntington’s disease models
Pluripotent stem cells undergo unlimited self-renewal while maintaining their potential to differentiate into post-mitotic cells with an intact proteome, a capacity that demands a highly induced proteostasis network. As such, induced pluripotent stem cells (iPSCs) suppress the aggregation of polyQ-e...
ORGANISM(S): Homo sapiens (Human) 
2018-06-14 | PXD009803 | Pride
Human cells (293) Htt 
ProteomicsSomatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein homeostasis (proteostasis) that would otherwise compromise stem cell identity. Here we show tha...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005123 | Pride
Neurons Chaperome Embryonic stem cells Neural progenitors cells 
ProteomicsComparison non-targeting hRNA hESCs versus UBE2K shRNA hESCs
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018625 | Pride
Histones Ubiquitin proteasome system Hescs 
UnknownDevelopment of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples.
Not available
S-EPMC5551177 | biostudies-literature
UnknownInjectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation.
Not available
S-EPMC8554763 | biostudies-literature
ProteomicsProteomics data of extruded germlines from C. elegans upon cey-3 RNAi
To shed light on how proteostasis defects in the germline influence somatic tissues, we first assessed the intracellular changes induced by PGL-1 aggregation in germline cells. For this purpose, we examined the proteome of isolated germlines from C. elegans following cey-3 knockdown
ORGANISM(S): Caenorhabditis elegans 
2021-04-28 | PXD025694 | Pride
C. elegans Germline Proteostasis 
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