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MetabolomicsMetabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in...
2019-09-06 | MTBLS598 | MetaboLights
MetabolomicsRelationship Between Vitamin D Levels and Psychological Stress-Induced Asthma Prevalence: An Untargeted Metabolomics Study Combined with the NHANES Database
The incidence of psychological stress–induced asthma has been increasing annually, and numerous previous studies have shown that vitamin D is associated with the development of asthma as well as anxiety and depression. However, no studies to date have clarified the relationship between vitamin D and...
2026-04-16 | MTBLS14208 | MetaboLights
TranscriptomicsUnderstanding Vitamin D resistance using Nonsense Mediated Decay arrays
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-06-01 | E-GEOD-9959 | biostudies-arrayexpress
ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsIdentification of vitamin K-dependent proteins in mouse liver by LC-MS/MS
Vitamin K (VK), a fat-soluble vitamin, functions as a co-factor during the gamma-carboxylation reaction that converts glutamic acid residues to gamma-carboxyglutamic acid residues in proteins transiting through the endoplasmic reticulum. Two enzymes are involved which together form the VK cycle: gam...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032920 | Pride
Gamma-carboxylation Mouse Liver Vitamin k Lc-ms/ms 
TranscriptomicsUnderstanding Vitamin D resistance using expression microarrays
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-9867 | biostudies-arrayexpress
TranscriptomicsEffects of vitamin A on ventricular myocardium gene expression [left ventricle]
LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age and gender matched wildtype mice on a vitamin A sufficient diet RNA was isolated from the left ventricle of the heart and one array was run for each sample.
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-74904 | biostudies-arrayexpress
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
ProteomicsA non-canonical vitamin K cycle is a potent ferroptosis suppressor
Raw files corresponding to LC-MS-based relative quantification of oxidized lipids in Pfa1 cells and mouse liver samples subjected to ferroptosis. Data were acquired in parallel reaction monitoring (PRM) MS/MS mode.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-05-19 | MSV000089489 | MassIVE
GenomicsEpigenomics of vitamin K response to supplementation
Epigenomics of vitamin K response to supplementation
PRJNA599955 | ENA
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