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ProteomicsUveal Melanoma Human Vitreous Proteome
The purpose of the project was to profile protein expression liquid vitreous biopsies from uveal melanoma (UM) patients using mass spectrometry, to identify prognostic biomarkers, signaling pathways, and therapeutic targets. Vitreous biopsies were collected from two cohorts: comparative control eyes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043403 | Pride
Vitreous Uveal melanoma Human 
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
ProteomicsDifferential proteomes in the vitreous of mice with a chronic hypoxic response in photoreceptors
Reduced oxygenation of photoreceptors and the RPE in the ageing eye may be a risk factor for the development of both neovascular and dry AMD. Chronic activation of the molecular response to hypoxia in RPE or photoreceptors leads to retinal degeneration that depends on hypoxia inducible transcription...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-12 | PXD008911 | Pride
Retinal degeneration Vitreous Cones Rods Hypoxic response Amd Shot-gun proteomics 
UnknownIn-depth mass spectrometric mapping of the human vitreous proteome.
Not available
S-EPMC3689628 | biostudies-literature
ProteomicsALTERED PATTERN OF PROTEOLYSIS OF EXTRACELLULAR PROTEINS IN RHEGMATOGENOUS RETINAL DETACHMENT BY MINING OF TRYPTIC AND N-TERMINI DATASETS FROM VITREOUS HUMOR PROTEOME
Retinal detachment is a severe eye condition characterized by the detachment of the neurosensory retina from the retinal pigment epithelium and caused by retinal tears. Pars plana vitrectomy is the elective surgical procedure during which vitreous humor, a fluid which shapes the eye globe and suppor...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD057155 | Pride
Eye Vitreous humor Uhplc-ms Ocular fluids Dda 
ProteomicsProteomic analysis of human vitreous humor
In this study, we investigated the proteome of normal human vitreous humor using high resolution Fourier transform mass spectrometry. We identified 1269 proteins. This largest catalog of vitreous proteins to date should facilitate biomedical research into pathological conditions of the eye including...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD000957 | Pride
Retina Body fluid proteomics Protein biomarkers 
ProteomicsSystem-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. Despite the success of anti-VEGF therapy as an effective therapy, many DR patients do not respond well to the treatment, emphasizing the involvement of other molecular players. To unveil these, we...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD036033 | Pride
Vitreous humor/diabetic retinopathy/ectodomain shedding/sheddase 
ProteomicsDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocula...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-09-13 | PXD009525 | Pride
Eye Vitreous Thermogelling polymer Retinal detachment repair Rabbit 
ProteomicsVitreous proteome of transgenic INSC94Y pigs compared to wild type
INSC94Y transgenic pigs serve as a valuable model for permanent neonatal diabetes mellitus. Through genetically engineered modifications in the insulin (INS) gene, this model presents with impaired insulin secretion, resulting elevated fasting blood-glucose levels (hyperglycemia) [1].One of the seve...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-08-27 | PXD038198 | Pride
Quantitative label-free lc-ms/ms  diabetes mellitus  permanent neonatal diabetes  diabetic retinopathy  genetically modified pig  insc94y  porcine model  vitreous 
ProteomicsComparative Proteomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment and Diabetic Retinopathy
The vitreous humor can provide important information about physiological and pathophysiological processes within the eye, particularly concerning the retina. Despite the widespread prevalence of various vitreoretinal diseases, that can ultimately lead to blindness, there is not a clear understanding...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD050611 | Pride
Diabetic retinopathy Human vitreous humor Rhegmatogenous retinal detachment 
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