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ProteomicsIs there a serum proteome signature to predict mortality in severe COVID-19 patients?
Here we recorded serum proteome profiles of 33 COVID-19 patients admitted to the ICU. We received, for most patients, blood samples just after admission and at two more later timepoints. We focused on serum proteins different in abundance between the group of survivors and non-survivors and observed...
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD024707 | Pride
Covid-19 Sars-cov2 Dia Human Serum Plasma Blood Mortality Longitudinal Biomarker 
ProteomicsRenal cell-derived extracellular vesicles as a modulator of tubuloid functional maturation
Tubuloids are adult stem cell-based kidney organoids with promising application in kidney disease modelling and drug screening. However, tubuloids still present limited transepithelial transport capacity, which is essential for the kidney’s function. The extracellular vesicles (EVs) are cell-derived...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD027142 | Pride
Proteomics Extracellular vesicles Tubuloids Kidney organoids Organic ion transporter 1 
ProteomicsFarnesylated Heat Shock Protein 40 is a component of membrane-bound RISC in Arabidopsis
ARGONAUTE1 (AGO1) binds directly to small regulatory RNA and is a key effector protein of post-transcriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA). The formation of an RNA induced silencing complex (RISC) of AGO1 and small RNA requires the function of the He...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-09-10 | PXD010197 | Pride
Chaperones Small rna Farnesylation Polysomes. Argonaute Rough er 
ProteomicsThe proteolytically inactive orthocaspase of Synechocystis sp. PCC 6803 plays an important role during oxidative stress
Caspases are proteases, best known for their involvement in the execution of apoptosis – a subtype of programmed cell death, which occurs only in animals. These proteases are composed of two structural building blocks: a proteolytically active p20 domain and a regulatory p10 domain. Although structu...
ORGANISM(S): Synechocystis sp. PCC 6803 
2021-09-09 | PXD022955 | Pride
Programmed cell death Orthocaspases Stress Metacaspases Pseudo-enzymes Cyanobacteria. 
ProteomicsHigh-dose oncogenic PIK3CA drives constitutive cellular stemness through increased NODAL/TGFb signaling
Oncogenic PIK3CA mutations activate phosphoinositide 3-kinase (PI3K) and are among the commonest somatic mutations in cancer and mosaic, developmental overgrowth disorders. We recently demonstrated that the ‘hotspot’ variant PIK3CAH1047R exerts striking allele dose-dependent effects on stemness in h...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD014719 | Pride
Proteomics Tfgb Nodal ipsc Cancer Transcriptomics Pik3ca 
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