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The vast number of noncoding RNAs in bacteria suggests that major post-transcriptional circuits beyond those controlled by the global RNA-binding proteins Hfq and CsrA may exist. To identify additional globally acting RNPs we have developed a method (gradient profiling by sequencing; Grad-seq) to pa...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2017-07-21 | PXD003360 | Pride
RNA-binding proteins (RBPs) play important roles in bacterial gene expression and physiology but their true number and functional scope remain little understood even in model microbes. To advance global RBP discovery in bacteria, we here establish glycerol gradient sedimentation with RNase treatment...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Bacteria 
2020-07-16 | PXD018422 | Pride
Neisseria meningitidis, the meningococcus, bears the potential of life-threatening invasive diseases, but it usually colonizes the nasopharynx without causing any symptoms. Within the nasopharynx, Neisseria meningitidis must face temperature changes depending on the ambient air temperature. Indeed, ...
ORGANISM(S): Neisseria meningitidis serogroup B (strain MC58) 
2016-10-10 | PXD003690 | Pride
Neisseria meningitidis (meningococcus) is usually transmitted via respiratory droplets, whereas its close relative, the gonococcus is sexually transmitted. Invasive meningococcal disease due to isolates of serogroup C increased in Europe and the United States among men who have sex with men (MSM). ...
ORGANISM(S): Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 
2016-05-18 | PXD001498 | Pride
Although usually a harmless colonizer of the human nasopharynx, Neisseria meningitidis (meningococcus) can spread to the blood stream and cause invasive disease. For survival in blood, N. meningitidis evades the complement system by expression of a polysaccharide capsule and surface proteins sequest...
ORGANISM(S): Neisseria meningitidis 
2019-02-28 | PXD010505 | Pride
KA-PARP1 was expressed in HeLa-KO PARP1 cells. Protein targets of KA-PARP1 were determined in cell lysate by using a DTB-modified NAD+analog.
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD046956 | Pride
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