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UnknownLangerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells.
Not available
S-EPMC5828466 | biostudies-literature
ProteomicsGlobal Identification of the miR-130a targetome in human HSPC Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML
Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells have firmly established the existence of shared core stemness properties. However, the discordance between mRNA and protein signatures underscores an important role for post-transcriptional regulation by...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD027331 | Pride
Lc-ms Acute myeloid leukemia Mirna Hematopoiesis 
UnknownA T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis.
Not available
S-EPMC8490410 | biostudies-literature
TranscriptomicsGene expression variation in lymphocyte subpopulations in response to low dose of ionizing radiations
Lymphocytes are the standard cell of a majority of biodosimetry approaches because of their availability and radiosensitivity. But progresses remain to be performed to bring down the minimum threshold of dose sensitivity. To find a lymphocyte subtype able to respond to low doses of ionizing radiatio...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-6978 | biostudies-arrayexpress
UnknownThe NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer.
Not available
S-EPMC10948531 | biostudies-literature
UnknownInterleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Not available
S-EPMC8133394 | biostudies-literature
ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
UnknownTCR-independent CD137 (4-1BB) signaling promotes CD8<sup>+</sup>-exhausted T cell proliferation and terminal differentiation.
Not available
S-EPMC10649891 | biostudies-literature
ProteomicsDissecting the molecular mechanisms of mother-to-egg immune protection in the mealworm beetle Tenebrio molitor
In a number of species, individuals exposed to pathogens can mount an immune response and transmit this immunological experience to their offspring, thereby protecting them against persistent threats. Such vertical transfer of immunity, named trans-generational immune priming (TGIP), has been descri...
ORGANISM(S): Tenebrio molitor 
2020-10-08 | PXD018772 | Pride
Trans-generational immune priming  invertebrate immunity  host-pathogens interaction  molecular mechanisms  omics  antimicrobial peptides 
ProteomicsBioID Assay of BirA*-hARGLU1 or BirA*-hGR in Flp-In T-Rex 293 cells
ARGLU1 is a Transcriptional Coactivator and Splicing Regulator Important for Stress Hormone Signaling and Development Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modu...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD012555 | Pride
Nr3c1 Splicing Gr Arglu1 
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