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TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
TranscriptomicsDetecting lung tumors from circulating microRNA profiles
We aimed to determine if lung cancer detection can be improved by circulating miRNAs as biomarkers. To this end, we collected blood of over 3000 individuals using PAXgene blood tubes. The individuals were diagnosed with lung cancer (LCa), a non-tumor lung disease (NTLD), another disease (OD) or were...
ORGANISM(S): Homo sapiens 
2020-05-19 | E-MTAB-8026 | biostudies-arrayexpress
TranscriptomicsTimecourse analysis of human colorectal cancer organoids under FOLFIRI chemotherapy
Two human colorectal cancer organoids derived from liver metastasis of the same patient were grown for seven days, then treated with FOLFIRI chemotherapy in vitro and sampled at different timepoints for single-cell RNA-sequencing. Time points include 0 h, 12 h, 24 h, 48 h, 72 h and 120 h on-treatmen...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16836 | biostudies-arrayexpress
TranscriptomicsTime course analysis of human colorectal cancer organoid treatment with Sacituzumab Govitecan (SG) or untargeted control IgG1-SN-38
Human colorectal cancer organoids were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38. Samples were harvested at different time points under treatment {0h, 3h, 6h, 9h, 12h} as well as after drug washout at 12 h on the following...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16843 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of colorectal cancer PDOX tumors treated with vehicle or the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan
Patient-derived colorectal cancer organoids were injected into mice to grow into subcutaneous tumors. Starting at 100 mm3, tumors were treated with Trodelvy (Sacituzumab Govitecan (SG)) or vehicle twice per week for 28 days before samples were harvested and subjected to single-cell RNA-sequencing of...
ORGANISM(S): Homo sapiens 
2026-04-29 | E-MTAB-16433 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of PDOX colorectal tumors
Patient-derived colorectal cancer organoids were injected into mice to grow into subcutaneous tumors. Tumors were profiled through multiplexed single-cell RNA-sequencing.
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16585 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of primary colorectal cancer tumor tissue and liver metastasis
Primary tumor or liver metastasis biopsies were obtained from colorectal cancer patients and processed for multiplexed single-cell RNA-sequencing.
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16583 | biostudies-arrayexpress
TranscriptomicsTime course analysis of human colorectal cancer liver metastasis models under Sacituzumab Govitecan (SG) treatment or untargeted control
Human colorectal cancer organoids were injected intrasplenically to form liver metastasis in mice were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38 (ADC). Tumors were harvested at different time points: 0 h, 6 h, 24 h, 48 h,...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16849 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of murine colorectal cancer tumors
Murine adenocarcinoma models VAKPS (Villin1-CreER Apc-fl/+ Kras-G12D/+ Trp5-3fl/fl Smad4-fl/fl) and VKPN (Villin1-CreER Kras-G12D/+ Trp53-fl/fl Rosa26-N1icd/+) were injected into mice to grow into subcutaneous tumors. Tumors were profiled through multiplexed single-cell RNA-sequencing.
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16835 | biostudies-arrayexpress
ModelsModeling the relevance of immune and metabolic cues in the macrophage/fibroblast interplay during fibrosis applied to kidney transplantation
In this model, we integrate in vitro observations of macrophage/fibroblasts in coculture with hypoxia and inflammatory signals. We obtain conditions under which the wound healing process progresses normally or becomes fibrotic.
2022-09-27 | MODEL2209160001 | BioModels
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