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ProteomicsQuantitative proteomics of the SMAD transcription factor family reveals IPO5 as a BMP Receptor-SMAD specific importin
Gene-specific transcription factors (GSTFs) control of gene transcription by DNA binding and specific protein complex recruitment, which regulates promoter accessibility for transcription initiation by RNA polymerase II. GSTFs that are frequently mutated in colon and rectal carcinomas are Suppressor...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004529 | Pride
Transcription regulation Proteomics Smad transcription factor Mass spectrometry Nuclear translocation 
ProteomicsAberrant neurodevelopment in human iPS cell-derived models of Alexander disease
Alexander disease (AxD) is a rare, severe neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, existing studies suggest that the mutant GFAP influences many cellular processes, including cytoskeleton stabilit...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD048606 | Pride
Scrna-seq Alexander disease Gfap Ips cells Brain organoids 
ProteomicsA farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona
Correct chromosome segregation during cell division depends on proper connections between spindle microtubules and kinetochores. During prometaphase, kinetochores are temporarily covered with a dense protein meshwork known as the fibrous corona. Formed by oligomerization of ROD/ZW10/ZWILCH-SPINDLY (...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD040338 | Pride
Cenp-e Farnesylation Kinetochores Chromosome segregation Rod/zw10/zwilch-spindly (rzz-s) complex 
ProteomicsFusion partners influence cellular and molecular phenotypes of oncogenic BRAF fusions
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic fusions, with fusion frequencies of 0.2-3% throughout different cancers. However, BRAF fusions rarely occur in the same gene conf...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD013461 | Pride
Resistance Crc Fusion partner Organoids Braf Signaling Fusion genes 
ProteomicsCysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
p16INK4A inhibits the CDK4/6 kinases and is therefore an important cell cycle regulator. Accumulation of p16INK4A in response to oncogenic transformation leads to cellular senescence and it is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of cellular oxid...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD012353 | Pride
Cysteine oxidation amyloid fibril p16ink4a 
ProteomicsDe novo heterozygous variants in POLR2A cause a neurodevelopmental syndrome with infantile-onset hypotonia
  ABSTRACT POLR2A encodes RPB1, the largest subunit of the RNA polymerase II (pol II) complex, which is responsible for transcription of all ~21,000 protein-encoding genes. Here we describe the first fifteen patients harboring de novo heterozygous variants in POLR2A. The majority presents with profo...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD011355 | Pride
Rpb1 De novo heterozygous variants Polr2a Rna polymerase ii 
OtherEvolutionary Acquisition of Cysteines determines FOXO Paralog-Specific Redox Signaling
Data from ProteomeXchange, PXD ID: PXD001018. Experiment: HRV_A, file: folder summary. Published as part of Antioxid Redox Signal. 2014 Jul 29 . From the Abstract: {{i}} Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is med...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320002469 | GPMDB
Resource Reanalysis 
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