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UnknownThe Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
Not available
S-EPMC4018046 | biostudies-literature
ProteomicsGlobal and phospho-proteome of Hek293T treated with kinase inhibitors
We examine the changes in HEK293T overexpressing alpha-synucleinA53T-GFP when treated with kinase inhibitors (SB203580, GF109203X,SB202190, Enzastaurin, VX-745). Main findings is altered protein translation, with an increase in lysosomal proteins for all compounds save VX-745
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD024508 | Pride
Lc-msms Enzastaurin Hek293t Alpha-synuclein Gf109203x Sb202190 Vx-745 Sb203580 
MultiomicsVX-745 KINOMEscan
For the panel of kinases, the Kd is measured using 11 serial threefold dilutions of VX-745.
2016-06-03 | LDS-1159 | LINCS
UnknownInhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.
Not available
S-EPMC5761097 | biostudies-literature
UnknownPleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts.
Not available
S-EPMC8787058 | biostudies-literature
ProteomicsRole of p38α MAPK in Monkeypox Virus Replication and Neuroinvasion: Implications for Therapeutic Targeting
Monkeypox virus (MPXV), a re-emerging zoonotic orthopoxvirus, has been increasingly linked to neurological manifestations in both patients and in experimental models. However, the mechanisms underlying MPXV-induced neural injury remain unclear. In non-human primate (NHP) model, we observed MPXV repl...
ORGANISM(S): Homo Sapiens 
2025-12-09 | PXD071786 |
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