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ProteomicsLC-MS analysis of Murine eIF4E-BP1/2 Double Knockout naive and TCR stimulated CD4+ T cells
This project focuses on examining the differences in the global CD4+ T cell proteome between cells lacking the negative regulators of eIF4E( eIf4E-Binding Proteins 1/2) and WT naive CD4+ T cells both prior and following TCR stimulation.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-20 | PXD039635 | Pride
Translational regulation Immunology Cd4+ t cells Murine Eif4e 
TranscriptomicsPRONOUNCED PHENOTYPE IN ACTIVATED TREG CELLS DURING A CHRONIC HELMINTH INFECTION
Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic he...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-17580 | biostudies-arrayexpress
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsExpression profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells
Investigation of expression effects of HSP90 inhibition by 17-AAG of proteins in resting and activated T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008627 | Pride
Hsp90 Anti-cd28 Activated t-cells Resting t-cells 17-aag Primary t-cells Anti-cd3 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in resting T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008635 | Pride
Hsp90 17-aag Mpdp Primary t-cells 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in activated T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008634 | Pride
Hsp90 Anti-cd28 Activated t-cells 17-aag Mpdp Primary t-cells Anti-cd3 
TranscriptomicsEarly-induced genes of human regulatory CD4+CD25hi Treg and CD4+CD25- Th cells
Goals and objectives of this study: to identify genes preferentially induced in human CD4+CD25hi Treg cells following T-cell activation with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, comparative gene expressio...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13017 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human regulatory T cells to identify genes under Foxp3 control
Foxp3, a transcription factor of the forkhead/winged helix family, plays a unique role in the transcriptional control of regulatory CD4+CD25+ T (Treg) cells. The identification of potential target genes associated with the regulatory phenotype and the characterization of combinatorial interactions o...
ORGANISM(S): Homo sapiens 
2005-01-24 | E-MEXP-228 | biostudies-arrayexpress
ProteomicsT-cell protein half live - Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis
Determine half lives of proteins in T-cells using dynamic SILAC labeling
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008630 | Pride
Dynamics silac Turnover Half live 
TranscriptomicsHuman activated Treg cells and retrovirally engineered Th cells, transduced with GARP, FOXP3 or control GFP vector
Goals and objectives of this study: to identify genes of the Treg signature induced by consitutive expression of GARP or FOXP3 in antigen-specific Th cells with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, compar...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13234 | biostudies-arrayexpress
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